Evidence map›Paper›PMID 35255549›Full record

SynthesisDiabetes & metabolism journal2022

Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis.

Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes & metabolism journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tianqi ZhangCentre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Marnie ShawCentre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Nicolas CherbuinCentre for Research on Ageing, Health and Wellbeing, The Australian National University, Canberra, Australia.
Australian National University · AU

Funding

Diabetes Status and Brain Amyloid in Middle Aged HispanicsR01AG050440 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LUCHSINGER, JOSE ALEJANDRO · 2015 to 2025
$21.9M
Interdisciplinary Research to Understand the Interplay of Diabetes, Cerebrovascular disease and Alzheimers diseaseRF1AG051556 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M, LUCHSINGER, JOSE ALEJANDRO · 2015 to 2019
$9.7M
Midcareer Award for Research in Dementia Risk Factors and PreventionK24AG045334 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jose Alejandro Luchsinger · 2016 to 2026
$1.5M
NIA NIH HHS K24 AG045334NIA NIH HHS R01 AG050440NIA NIH HHS RF1 AG051556
6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) is known to be associated with cognitive decline and brain structural changes. This study systematically reviews and estimates human brain volumetric differences and atrophy associated with T2DM.

methodsPubMed, PsycInfo and Cochrane Library were searched for brain imaging studies reporting on brain volume differences between individuals with T2DM and healthy controls. Data were examined using meta-analysis, and association between age, sex, diabetes characteristics and brain volumes were tested using meta-regression.

resultsA total of 14,605 entries were identified; after title, abstract and full-text screening applying inclusion and exclusion criteria, 64 studies were included and 42 studies with compatible data contributed to the meta-analysis (n=31,630; mean age 71.0 years; 44.4% male; 26,942 control; 4,688 diabetes). Individuals with T2DM had significantly smaller total brain volume, total grey matter volume, total white matter volume and hippocampal volume (approximately 1% to 4%); meta-analyses of smaller samples focusing on other brain regions and brain atrophy rate in longitudinal investigations also indicated smaller brain volumes and greater brain atrophy associated with T2DM. Meta-regression suggests that diabetes-related brain volume differences start occurring in early adulthood, decreases with age and increases with diabetes duration.

conclusionT2DM is associated with smaller total and regional brain volume and greater atrophy over time. These effects are substantial and highlight an urgent need to develop interventions to reduce the risk of T2DM for brain health.

Indexed as

Diabetes Mellitus, Type 2AdultAgedAtrophyBrainFemaleHumansMagnetic Resonance ImagingMaleAtrophyBrainDiabetes mellitus, type 2Neuroimaging

Identifiers

PMID35255549
PMCPMC9532183
OpenAlexW4220902329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.