ArticleNature2022
Whole-genome sequencing reveals host factors underlying critical COVID-19.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 10 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 10 pooled it
33.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
207 citing papers in PubMed, 10 syntheses or guidelines pooled it, 341 citations in OpenAlex.
- Genome-Wide Association Studies of Hospitalized Influenza Identify Four Risk Loci and Reveal Shared and Unique Genetic Factors Compared With COVID-19.Influenza and other respiratory viruses · 2026Pooled it
- Sex-specific autosomal susceptibility loci in systemic sclerosis: a genome-wide association study.The Lancet. Rheumatology · 2026Pooled it
- Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19.EBioMedicine · 2025Pooled it
- Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies.Nutrition reviews · 2025Pooled it
- Mucosal immune response in biology, disease prevention and treatment.Signal transduction and targeted therapy · 2025Pooled it
- Potential use of sodium glucose co-transporter 2 inhibitors during acute illness: a systematic review based on COVID-19.Endocrine · 2024Pooled it
- Canadian COVID-19 host genetics cohort replicates known severity associations.PLoS genetics · 2024Pooled it
- Causal association of COVID-19 with brain structure changes: Findings from a non-overlapping 2-sample Mendelian randomization study.Journal of the neurological sciences · 2023Pooled it
- Pooled it
- Novel genes and sex differences in COVID-19 severity.Human molecular genetics · 2022Pooled it
- Genetic factors associated with COVID-19 severity and mortality: TYK2 and NOTCH4.Biomedical reports · 2026Article
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- Article
- Plscr1 inhibits murine norovirus entry.bioRxiv : the preprint server for biology · 2026Article
- Trop-1/EpCAM Thr115 is a driver of hyperproliferative cell repair and of severe lung damage in COVID-19.iScience · 2026Article
- Functional diversity of natural humanScience advances · 2026Article
- Mitochondrial Function-Related Genes in Sleep Disorders: A Multi-Omics Mendelian Randomization Study.Journal of molecular neuroscience : MN · 2026Article
- Mucins and Respiratory Virus Infection.Annual review of virology · 2026Review
- Article
- Evolution ofInternational journal of molecular sciences · 2026Review
147 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
79 authors at 20 institutions in 23 countries.
Athanasios Kousathanas *Genomics England, London, UK.ORCID http://orcid.org/0000-0001-6265-6521
Erola Pairo-Castineira *Roslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2423-3090
Konrad RawlikRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0010-370X
Alex StuckeyGenomics England, London, UK.
Christopher A OdhamsGenomics England, London, UK.
Susan WalkerGenomics England, London, UK.ORCID http://orcid.org/0000-0002-5016-6426
Clark D RussellRoslin Institute, University of Edinburgh, Edinburgh, UK.
Tomas MalinauskasWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4847-5529
Yang WuInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-0128-7280
Jonathan MillarRoslin Institute, University of Edinburgh, Edinburgh, UK.
Xia ShenBiostatistics Group, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.ORCID http://orcid.org/0000-0003-4390-1979
Katherine S ElliottWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8125-797X
Fiona GriffithsRoslin Institute, University of Edinburgh, Edinburgh, UK.
Wilna OosthuyzenRoslin Institute, University of Edinburgh, Edinburgh, UK.
Kirstie MorriceEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Sean KeatingIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-8552-5604
Bo WangRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1580-797X
Daniel RhodesGenomics England, London, UK.
Lucija KlaricMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3105-8929
Marie ZechnerRoslin Institute, University of Edinburgh, Edinburgh, UK.
Nick ParkinsonRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6336-5654
Afshan SiddiqGenomics England, London, UK.
Peter GoddardGenomics England, London, UK.
Sally DonovanGenomics England, London, UK.
David MasloveDepartment of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada.
Alistair NicholClinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-4689-1238
Malcolm G SempleNIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9700-0418
Tala ZainyGenomics England, London, UK.
Fiona Maleady-CroweGenomics England, London, UK.
Linda ToddGenomics England, London, UK.
Shahla SalehiGenomics England, London, UK.ORCID http://orcid.org/0000-0002-5058-7706
Julian KnightWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-0377-5536
Greg ElgarGenomics England, London, UK.ORCID http://orcid.org/0000-0001-7323-1596
Georgia ChanGenomics England, London, UK.
Prabhu ArumugamGenomics England, London, UK.
Christine PatchGenomics England, London, UK.ORCID http://orcid.org/0000-0002-4191-0663
Augusto RendonGenomics England, London, UK.
David BentleyIllumina Cambridge, Great Abington, UK.
Clare KingsleyIllumina Cambridge, Great Abington, UK.
Jack A KosmickiRegeneron Genetics Center, Tarrytown, NY, USA.
Julie E HorowitzRegeneron Genetics Center, Tarrytown, NY, USA.
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
Goncalo R AbecasisRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-1509-1825
Manuel A R FerreiraRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-9059-1825
Anne JusticeGeisinger, Danville, PA, USA.
Tooraj MirshahiGeisinger, Danville, PA, USA.
Matthew OetjensGeisinger, Danville, PA, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Marylyn D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1208-1720
Anurag VermaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Tom A FowlerGenomics England, London, UK.
Manu Shankar-HariDepartment of Intensive Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-5338-2538
Charlotte SummersDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-7269-2873
Charles HindsWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0001-5094-8324
Peter HorbyCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lowell LingDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
Danny McAuleyWellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-3283-1947
Hugh MontgomeryUCL Centre for Human Health and Performance, London, UK.ORCID http://orcid.org/0000-0001-8797-5019
Peter J M OpenshawNational Heart and Lung Institute, Imperial College London, London, UK.
Paul ElliottImperial College, London, UK.ORCID http://orcid.org/0000-0002-7511-5684
Timothy WalshIntensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.
Albert TenesaRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4884-4475
GenOMICC investigators
23andMe investigators
COVID-19 Human Genetics Initiative
Angie FawkesEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Lee MurphyEdinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-6467-7449
Kathy RowanIntensive Care National Audit and Research Centre, London, UK.ORCID http://orcid.org/0000-0001-8217-5602
Chris P PontingMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0202-7816
Veronique VitartMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4991-3797
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Jian YangSchool of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0003-2001-2474
Andrew D BretherickMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-9258-3140
Richard H ScottGenomics England, London, UK.
Sara Clohisey HendryRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7489-9846
Loukas MoutsianasGenomics England, London, UK.ORCID http://orcid.org/0000-0001-5453-345X
Andy LawRoslin Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1868-2364
Mark J CaulfieldGenomics England, London, UK. m.j.caulfield@qmul.ac.uk.ORCID http://orcid.org/0000-0001-9295-3594
J Kenneth BaillieRoslin Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.ORCID http://orcid.org/0000-0001-5258-793X
Roslin Institute · GBUniversity of Liverpool · GBUniversity of Siena · ITIcahn School of Medicine at Mount Sinai · USWestern General Hospital · GBRoyal Hallamshire Hospital · GBMcGill University · CABarts Health NHS Trust · GBGenomics England · GBRoyal Shrewsbury Hospital · GBRoyal Blackburn Teaching Hospital · GBSalford Royal Hospital · GBMassachusetts General Hospital · USSt George's Hospital · GBHuddersfield Royal Infirmary · GBWorcestershire Royal Hospital · GBDarent Valley Hospital · GBKing Abdulaziz City for Science and Technology · SANorth Manchester General Hospital · GBRoyal Surrey County Hospital · GB
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MPhenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MCreating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4MExpanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0MCOVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MMedical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_PC_17228Medical Research Council MC_PC_19025Medical Research Council MC_PC_19059Medical Research Council MC_PC_20004Medical Research Council MC_PC_20029Medical Research Council MC_PC_20058Medical Research Council MC_QA137853Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12008/1Medical Research Council MR/M009203/1Medical Research Council MR/N02995X/1Medical Research Council MR/R026408/1NCATS NIH HHS UL1 TR001878NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NIEHS NIH HHS P30 ES010126NIH HHS S10 OD026880NIH HHS S10 OD030463Wellcome Trust 204979/Z/16/ZWellcome Trust 210561/Z/18/ZWellcome Trust 223164/Z/21/Z
Abstract
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care
Indexed as
COVID-19Critical IllnessGenome, HumanHost-Pathogen InteractionsWhole Genome SequencingATP-Binding Cassette TransportersCell Adhesion MoleculesCritical CareDC-Specific ICAM-3 Grabbing NonintegrinE-SelectinFactor VIIIFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseGenome-Wide Association StudyHumansInterleukin-10 Receptor beta SubunitATP11A protein, humanATP-Binding Cassette TransportersBCL11A protein, humanCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinE-SelectinF8 protein, humanFactor VIIIFucosyltransferasesGalactoside 2-alpha-L-fucosyltransferaseICAM5 protein, humanIL10RB protein, humanInterleukin-10 Receptor beta SubunitLectins, C-TypeMUC1 protein, humanMucin-1Nerve Tissue ProteinsPhospholipid Transfer ProteinsPLSCR1 protein, humanReceptors, Cell SurfaceRepressor ProteinsSELE protein, human
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