ArticleEnvironment international2022
Impact of neighborhood socioeconomic status, income segregation, and greenness on blood biomarkers of inflammation.
Article in Environment international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Neighborhood Safety and Hypertension Risk: A Systematic Review.Journal of the American Heart Association · 2025Pooled it
- Differential expression of lymphocyte markers by neighborhood opportunity among US adults: Insights from the Midlife in the United States study.Psychoneuroendocrinology · 2026Article
- Perceived Neighborhood Disorder, Health Behaviors, and Inflammation Among Older Adults: A Mediation Analysis.Journal of aging and health · 2026Article
- Social determinants of health across the lifecourse and chronic disease risk: available data and seminal findings from the Atherosclerosis Risk in Communities (ARIC) Study.American journal of epidemiology · 2026Review
- Intake of Fiber From Different Food Sources and Type 2 Diabetes Risk: An Integrated Analysis of Epidemiological and Multiomic Data.Diabetes care · 2026Article
- Residential green space, walkability, and cardiometabolic biomarkers in midlife women: a longitudinal cohort study.Environmental research, health : ERH · 2026Article
- eHealth Literacy, self-management, and selected clinical and social correlates of nutrition-inflammation level among older adults with diabetes.BMC health services research · 2026Article
- Diet, physical activity, all-cause and cause-specific mortality: repeated measures considerations.European journal of epidemiology · 2026Article
- Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery.Journal of affective disorders reports · 2026Article
- Differential effects of neighborhood ambient PMInternational journal of health geographics · 2026Article
- Adherence to Healthy Lifestyle and Risk of Cardiometabolic Diseases in Individuals With Hypertension.JAMA network open · 2026Article
- Association between residential greenness and risks of diabetic complications among individuals with type 2 diabetes and the roles of healthy lifestyle behaviors.Eco-Environment & Health · 2026Article
- The Effect of Low Socioeconomic Status on the Leptin-to-Adiponectin Ratio.Nursing open · 2026Review
- Racialized economic segregation in relation to fecundability in a preconception cohort study.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Article
- Assessing greenspace and cardiovascular disease risk through deep learning analysis of street-view imagery in the US-based nationwide Nurses' Health Study.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Harnessing Geospatial Artificial Intelligence (GeoAI) for Environmental Epidemiology: A Narrative Review.Current environmental health reports · 2025Review
- Residential greenness and diabetes incidence in two prospective cohorts of US women.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Cross-Sectional and Longitudinal Associations of Neighborhood Disadvantage With Fluid Biomarkers of Neuroinflammation and Neurodegeneration.Neurology · 2025Article
- Fine particulate matter air pollution and longitudinal gray matter development changes during early adolescence: variation by neighborhood disadvantage level.Environment international · 2025Article
- Cross-sectional Associations of Neighborhood Social and Environmental Contextual Factors with Telomere Length in Male and Female Health Professionals.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundNeighborhood deprivation is linked with inflammation, which may explain poorer health across populations. Behavioral risk factors are assumed to largely mediate these relationships, but few studies have examined this. We examined three neighborhood contextual factors that could exert direct effects on inflammation: (1) neighborhood socioeconomic status, (2) an index of concentration at extremes (that measures segregation), and (3) surrounding vegetation (greenness).
methodsUsing blood samples and addresses collected from prospective cohorts of 7,930 male (1990-1994) and 16,183 female (1986-1990) health professionals with at least one inflammatory marker, we prospectively linked neighborhood contextual factors to inflammatory biomarkers (adiponectin, C-reactive protein, interleukin-6, soluble tumor necrosis factor receptor-2). Log-transformed, z-scaled component measures were used to calculate an inflammation score. Neighborhood socioeconomic status and index of concentration of extremes were obtained from the 1990 decennial census and linked to participant addresses. Surrounding greenness was assessed from satellite data and focal statistics were applied to generate exposures within 270 m and 1230 m of the participants' address. We fit multiple linear regression models adjusting for demographic, clinical, and behavioral risk factors.
resultsHigher neighborhood socioeconomic status was associated with lower inflammation score in women (β for interquartile range increase = -27.7%, 95% CI: -34.9%, -19.8%) and men (β = -21.2%, 95% CI: -31.0%, -10.1%). Similarly, participants in neighborhoods with higher concentrations of high-income households were associated with lower inflammation score in women (β = -27.8%, 95% CI: -35.8%, -18.7%) and men (β = -16.4%, 95% CI: -29.7%, -0.56%). Surrounding greenness within 270 m of each participant's address was associated with lower inflammation score in women (β = -18.9%, 95% CI: -28.9%, -7.4%) but not men. Results were robust to sensitivity analyses to assess unmeasured confounding and selection bias. DISCUSSION: Our findings support the hypothesis that adverse neighborhood environments may contribute to inflammation through pathways independent of behavioral risk factors, including psychosocial stress and toxic environments.
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