ArticleIEEE transactions on bio-medical engineering2022
Hybrid Mock Circulatory Loop Simulation of Extreme Cardiac Events.
Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Review of Cardiovascular Mock Circulatory Loop Designs and Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Technological evolution ofFrontiers in physiology · 2025Review
- Reproduction of human blood pressure waveform using physiology-based cardiovascular simulator.Scientific reports · 2023Article
- A Protocol for Coupling Volumetrically Dynamic In-Vitro Experiments to Numerical Physiology Simulation for a Hybrid Cardiovascular Model.IEEE transactions on bio-medical engineering · 2023Article
- A New Cardiovascular Mock Loop Driven by Novel Active Capacitance in Normal and Abnormal Conditions.Applied bionics and biomechanics · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThis paper presents preliminary methods of incorporating the pathological conditions of cardiac arrhythmias and valvular stenosis in hybrid mock circulation loop (hMCL) operation for the enhanced verification and validation of mechanical circulatory support devices such as VADs.
methodsThe MGH/MF Waveform datasets from PhysioNet database (including both nominal and clinically diagnosed arrhythmic ECG measurements) as well as cardiovascular system model updates are used to recreate arrhythmic events and valvular stenosis in vitro.
resultsPreliminary results show the hMCL can recreate each tested cardiac event within 2% and 4% mean error for reference pressure tracking in the aortic and left ventricular pressure chambers, respectively. Further, frequency spectrum analysis comparisons using the magnitude-squared coherence analysis shows close alignment between measured arrhythmic and hMCL realized pressure frequency content.
conclusionThe generation of cardiac arrhythmias and valvular stenosis around a VAD via both model and acute measurement based methods was achieved. SIGNIFICANCE: Pathological conditions such as cardiac arrhythmias and valvular stenosis are limited in documentation despite the large percentage of patients who experience these events. This paper provides a means to begin incorporating these events into hardware-in-the-loop mock circulatory systems for next generation VAD validation and verification.
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Registered trials
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