Evidence map›Paper›PMID 35254919›Full record

ArticleCirculation2022

Efficient In Vivo Homology-Directed Repair Within Cardiomyocytes.

Yanjiang Zheng, Nathan J VanDusen, Catalina E Butler, Qing Ma, Justin S King, William T Pu

Open access · bronzeAbstract readLetter
In one paragraph

Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  8. Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yanjiang Zheng *Department of Biochemistry, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China (Y.Z.).
Nathan J VanDusen *Department of Cardiology, Boston Children's Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.).ORCID 0000-0002-2636-7228
Catalina E ButlerDepartment of Cardiology, Boston Children's Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.).ORCID 0000-0002-0096-0197
Qing MaDepartment of Cardiology, Boston Children's Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.).
Justin S KingDepartment of Cardiology, Boston Children's Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.).
William T PuDepartment of Cardiology, Boston Children's Hospital, MA (Y.Z., N.J.V., C.E.B., Q.M., J.S.K., W.T.P.).ORCID 0000-0002-4551-8079
Boston Children's Hospital · USWest China Medical Center of Sichuan University · CN

Funding

Regulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4M
Regulation of Cardiomyocyte MaturationR01HL146634 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PU, WILLIAM TSWENCHING · 2019 to 2022
$2.4M
Functional dissection of the regulatory network that governs cardiomyocyte maturation.K99HL143194 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI VANDUSEN, NATHAN JAMES · 2019 to 2021
$232k
NHLBI NIH HHS K99 HL143194NHLBI NIH HHS R01 HL146634NHLBI NIH HHS UM1 HL098166
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Myocytes, CardiacRecombinational DNA RepairCRISPR-Cas SystemsGene EditingHumansCRISPR-associated protein 9genome editinghomology-directed dsDNA break repairmyocytes, cardiac

Identifiers

PMID35254919
PMCPMC9157414
OpenAlexW4220998635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.