Evidence map›Paper›PMID 35254915›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Proteome-wide cellular thermal shift assay reveals unexpected cross-talk between brassinosteroid and auxin signaling.

Qing Lu, Yonghong Zhang, Joakim Hellner, Caterina Giannini, Xiangyu Xu, Jarne Pauwels, Qian Ma, Wim Dejonghe, Huibin Han, Brigitte Van de Cotte and 6 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Qing LuDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0002-4703-3286
Yonghong ZhangDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.
Joakim HellnerPelago Bioscience AB, 171 48 Solna, Sweden.
Caterina GianniniInstitute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Xiangyu XuDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0002-6492-9770
Jarne PauwelsDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.
Qian MaDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0001-8718-0005
Wim DejongheDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-3869-2228
Huibin HanInstitute of Science and Technology Austria, 3400 Klosterneuburg, Austria.
Brigitte Van de CotteDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0001-7236-9243
Francis ImpensDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-2886-9616
Kris GevaertDepartment of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium.
Ive De SmetDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0003-4607-8893
Jiří FrimlInstitute of Science and Technology Austria, 3400 Klosterneuburg, Austria.ORCID 0000-0002-8302-7596
Daniel Martinez MolinaPelago Bioscience AB, 171 48 Solna, Sweden.
Eugenia RussinovaDepartment of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium.ORCID 0000-0002-0569-1977
Ghent University · BEInstitute of Science and Technology Austria · ATPelago Bioscience (Sweden) · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SignificanceChemical genetics, which investigates biological processes using small molecules, is gaining interest in plant research. However, a major challenge is to uncover the mode of action of the small molecules. Here, we applied the cellular thermal shift assay coupled with mass spectrometry (CETSA MS) to intact

Indexed as

ProteomeSignal TransductionAminopyridinesArabidopsisArabidopsis ProteinsBrassinosteroidsIndoleacetic AcidsPhosphoproteinsProtein BindingProtein StabilityProteomicsSuccinatesAminopyridinesArabidopsis ProteinsbikininBrassinosteroidsIndoleacetic AcidsPhosphoproteinsProteomeSuccinatesauxinbrassinosteroidscellular thermal shift assaychemical genetics

Identifiers

PMID35254915
PMCPMC8931322
OpenAlexW4221041567

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.