Evidence map›Paper›PMID 35254905›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

A commensal-encoded genotoxin drives restriction of

Jiandong Chen, Hyuntae Byun, Rui Liu, I-Ji Jung, Qinqin Pu, Clara Y Zhu, Ethan Tanchoco, Salma Alavi, Patrick H Degnan, Amy T Ma and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
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  6. Review
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  16. Article
  17. Current understandings of colibactin regulation.Microbiology (Reading, England) · 2024
    Review
  18. Article
  19. The synthesis of the novelFrontiers in microbiology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiandong ChenDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Hyuntae ByunDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Rui LiuDepartment of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
I-Ji JungDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0002-9740-6386
Qinqin PuDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Clara Y ZhuHarriton High School, Bryn Mawr, PA 19010.
Ethan TanchocoDepartment of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.ORCID 0000-0002-8851-2259
Salma AlaviDepartment of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
Patrick H DegnanDepartment of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
Amy T MaDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102.
Manuela RoggianiDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-8564-036X
Joris BeldDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102.ORCID 0000-0001-7070-663X
Mark GoulianDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104.
Ansel HsiaoDepartment of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
Jun ZhuDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.ORCID 0000-0001-9182-5224

Funding

Vibrio cholerae antinitrosative stress defenses and gut microbiome interactionR01AI157106 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HSIAO, ANSEL, ZHU, JUN · 2020 to 2024
$4.0M
Regulation of Bacterial Two-Component Signaling by Small Membrane ProteinsR01GM080279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2007 to 2020
$3.7M
ROS responses during Vibrio cholerae infectionR01AI120489 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZHU, JUN · 2016 to 2020
$2.4M
Phosphorelay signaling and regulation in bacteriaR35GM139541 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2021 to 2025
$2.0M
Gut microbiome-mediated small-molecule signaling and resistance to invading microorganismsR35GM124724 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI HSIAO, ANSEL · 2017 to 2021
$1.8M
The role of mannitol metabolism in toxigenic Vibrio cholerae pathogenesisR21AI137283 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZHU, JUN · 2018 to 2019
$443k
NIAID NIH HHS R01 AI120489NIAID NIH HHS R01 AI157106NIAID NIH HHS R21 AI137283NIGMS NIH HHS R01 GM080279NIGMS NIH HHS R35 GM124724NIGMS NIH HHS R35 GM139541
6 · The paper itself

Abstract

SignificanceIn a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of an

Indexed as

Gastrointestinal MicrobiomeHost-Pathogen InteractionsMicrobial InteractionsAnimalsAntibiosisCholeraDisease Models, AnimalDNA DamageEscherichia coliHumansMiceMutagensPeptidesPolyketidesPrognosisReactive Oxygen SpeciescolibactinMutagensPeptidesPolyketidesReactive Oxygen SpeciescolibactinmicrobiomeVibrio cholerae

Identifiers

PMID35254905
PMCPMC8931321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.