ArticleProceedings of the National Academy of Sciences of the United States of America2022
The life history of
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- A novel female reproductive organ differentiates insemination and postmating responses in bedbugs.Molecular biology and evolution · 2026Article
- Pervasive convergent evolution of sperm conjugation across the Arthropoda tree of life.Nature communications · 2026Review
- Evolution of the reproductive interactome and the origins of postmating-prezygotic reproductive divergence.BMC biology · 2026Article
- Article
- Neprilysin 4 controls acrosome structure and male fertility in Drosophila melanogaster.Communications biology · 2025Article
- Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs.bioRxiv : the preprint server for biology · 2025Article
- Correlated Gene Copy Number Changes in a Seminal Fluid Protein Network inbioRxiv : the preprint server for biology · 2025Article
- Evo-Inspired Engineering of Radical Phenotypes and Emergent Traits.Integrative and comparative biology · 2025Review
- Genomics of a sexually selected sperm ornament and female preference in Drosophila.Nature ecology & evolution · 2025Article
- Regional specialization, polyploidy, and seminal fluid transcripts in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Synthesis and Scope of the Role of Postmating Prezygotic Isolation in Speciation.Cold Spring Harbor perspectives in biology · 2024Review
- Females translate male mRNA transferred during mating.iScience · 2024Article
- Separation of reproductive decline from lifespan extension during methionine restriction.Nature aging · 2024Article
- An Orphan Gene Enhances Male Reproductive Success in Plutella xylostella.Molecular biology and evolution · 2024Article
- Reproductive isolation arises during laboratory adaptation to a novel hot environment.Genome biology · 2024Article
- Proteomic diversification of spermatostyles among six species of whirligig beetles.Molecular reproduction and development · 2024Article
- A fatty acid anabolic pathway in specialized-cells sustains a remote signal that controls egg activation in Drosophila.PLoS genetics · 2024Article
- Male-derived transcripts isolated from the mated female reproductive tract in Drosophila melanogaster.G3 (Bethesda, Md.) · 2023Article
- Cep104 is a component of the centriole distal tip complex that regulates centriole growth and contributes to Drosophila spermiogenesis.Current biology : CB · 2023Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
SignificanceIn species with internal fertilization, sperm spend an important part of their lives within the female. To examine the life history of the sperm during this time, we used semiquantitative proteomics and sex-specific isotopic labeling in fruit flies to determine the extent of molecular continuity between male and female reproductive tracts and provide a global catalog of sperm-associated proteins. Multiple seminal fluid proteins and female proteins associate with sperm immediately after mating. Few seminal fluid proteins remain after long-term sperm storage, whereas female-derived proteins constitute one-fifth of the postmating sperm proteome by then. Our data reveal a molecular "hand-off" from males to females, which we postulate to be an important component of sperm-female interactions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.