ArticleEnvironmental health perspectives2022
Associations between the Maternal Exposome and Metabolome during Pregnancy.
Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Health Biomarkers of Pesticide Exposure in Rural Populations of Santa Fe, Argentina: Oxidative Stress and Genotoxicity.Journal of applied toxicology : JAT · 2026Article
- Prevalent detection of multiclass environmental chemicals in paired CSF and plasma samples and their potential associations with postpartum depressive symptoms in pregnant women.Environmental research · 2026Article
- A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity.Journal of biochemical and molecular toxicology · 2026Review
- High-Throughput Suspect Screening Reveals Widespread Pesticide Exposure in Early Childhood.Environment & health (Washington, D.C.) · 2026Article
- Cognitive benefits of air purification among schoolchildren: A randomized, double-blind, crossover trial.Innovation (Cambridge (Mass.)) · 2026Article
- Application of non-targeted analysis for the identification of novel environmental contaminants in amniotic fluid.Journal of exposure science & environmental epidemiology · 2026Article
- Prenatal Metal Exposome Reprograms Neonatal Metabolism: Trimester-Dependent Effects on Amino Acid and Carnitine Networks.Environment & health (Washington, D.C.) · 2026Article
- Urinary Metabolites during Pregnancy: A Literature Review.ACS nutrition science · 2026Review
- Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme.Journal of advanced research · 2026Article
- Mapping of Determinants of Urinary Sex Steroid Metabolites During Late Pregnancy: Results from Two Spanish Cohorts.International journal of molecular sciences · 2025Article
- Reaction-Guided Metabolomics Accelerates High-Throughput Annotation of Xenobiotic Metabolites for Human Exposome.Environmental science & technology · 2025Article
- Prenatal Organophosphate Pesticide Exposure and Targeted Maternal Pregnancy Metabolomic Profiles in the NYU CHES Cohort.Environmental science & technology · 2025Article
- Identifying Metabolic Signatures of Bisphenol Analog Exposure: Implication for Rapid Toxicity Screening of New Alternatives.Environmental science & technology · 2025Article
- The mediating effect of maternal blood lipids on the association between maternal exposure to PMLipids in health and disease · 2025Article
- Global research trends on the human exposome: a bibliometric analysis (2005-2024).Environmental science and pollution research international · 2025Review
- Association analysis of maternal exposure to air pollution during pregnancy and offspring asthma incidence.Reproductive health · 2025Article
- Liquid crystal monomers induce placental development and progesterone release dysregulation through transplacental transportation.Nature communications · 2025Article
- Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy.Environmental health : a global access science source · 2024Article
- Linking Prenatal Environmental Exposures to Lifetime Health with Epigenome-Wide Association Studies: State-of-the-Science Review and Future Recommendations.Environmental health perspectives · 2023Review
- Early Pregnancy Markers in the Serum of Ewes Identified via Proteomic and Metabolomic Analyses.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundMaternal exposure to environmental chemicals during pregnancy can influence various maternal and offspring health parameters. Modification of maternal metabolism by environmental exposure may be an important pathway for these impacts. However, there is limited evidence regarding exposure to a wide array of chemicals and the metabolome during pregnancy.
objectivesWe investigated the relationship between the urinary exposome and metabolome during pregnancy.
methodsUrine samples were collected in the first and third trimesters from 1,024 pregnant women recruited in prenatal clinics in Jiangsu Province, China. The exposome was analyzed using the first trimester sample with ultra-high performance liquid chromatography-high resolution accurate mass spectrometry (UHPLC-HRMS) and inductively coupled plasma mass spectrometry. The metabolome was analyzed using the third trimester sample with UHPLC-HRMS. We evaluated associations between each of 106 exposures in the first trimester with 139 metabolites in the third trimester.
resultsWe identified 1,245 significant associations ( DISCUSSION: This high-dimensional analysis of the urinary exposome and metabolome identified many associations between chemical exposures and maternal metabolism during pregnancy. Integration of these associations with the literature on health outcomes of exposure suggests that environmental modulation of the maternal metabolome may play a role in the association between prenatal exposure on pregnancy and child health outcomes. https://doi.org/10.1289/EHP9745.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.