ArticleEMBO reports2022
Long-distance mobile mRNA CAX3 modulates iron uptake and zinc compartmentalization.
Article in EMBO reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Developing a mobile RNA delivery system for grafting trait improvement.EMBO reports · 2026Article
- Integrated physiological, element content, transcriptomic and weighted gene co-expression network analysis provide insights into the response mechanisms of Areca catechu to Zn/Fe deficiency stress.BMC plant biology · 2026Article
- Time-Series Elemental Imaging Reveals CAX-Dependent Redistribution Patterns for Anoxia Recovery.Journal of experimental botany · 2025Article
- Decoding Long-Distance Communication Under Mineral Stress: Advances in Vascular Signalling and Molecular Tools for Plant Resilience.Plant, cell & environment · 2025Review
- Rhizosphere microorganisms mediate ion homeostasis in cucumber seedlings: a new strategy to improve plant salt tolerance.BMC plant biology · 2025Article
- The biology of grafting and its applications in studying information exchange between plants.Nature plants · 2025Review
- Mobile RNAs as systemic signaling beyond boundaries for plant stress resistance.Frontiers in plant science · 2025Review
- Scion-to-Rootstock Mobile Transcription FactorInternational journal of molecular sciences · 2022Article
- Long-distance mobile mRNA CAX3 modulates iron uptake and zinc compartmentalization.EMBO reports · 2022Article
- Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron deficiency in plants can lead to excessive absorption of zinc; however, important details of this mechanism have yet to be elucidated. Here, we report that MdCAX3 mRNA is transported from the leaf to the root, and that MdCAX3 is then activated by MdCXIP1. Suppression of MdCAX3 expression leads to an increase in the root apoplastic pH, which is associated with the iron deficiency response. Notably, overexpression of MdCAX3 does not affect the apoplastic pH in a MdCXIP1 loss-of-function Malus baccata (Mb) mutant that has a deletion in the MdCXIP1 promoter. This deletion in Mb weakens MdCXIP1 expression. Co-expression of MdCAX3 and MdCXIP1 in Mb causes a decrease in the root apoplastic pH. Furthermore, suppressing MdCAX3 in Malus significantly reduces zinc vacuole compartmentalization. We also show that MdCAX3 activated by MdCXIP1 is not only involved in iron uptake, but also in regulating zinc detoxification by compartmentalizing zinc in vacuoles to avoid iron starvation-induced zinc toxicity. Thus, mobile MdCAX3 mRNA is involved in the regulation of iron and zinc homeostasis in response to iron starvation.
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