ArticleThe New phytologist2022
NUCLEOCYTOPLASMIC shuttling of ETHYLENE RESPONSE FACTOR 5 mediated by nitric oxide suppresses ethylene biosynthesis in apple fruit.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Nitric oxide-centred signaling networks in plants: from growth to postharvest.Frontiers in plant science · 2026Review
- A FnWRKY17-Frontiers in plant science · 2026Article
- Nitric oxide delays yellowing by regulating chloroplast membrane lipid metabolism and the ascorbate-glutathione cycle in postharvest broccolini.Frontiers in nutrition · 2026Article
- MdMAPK6-mediated phosphorylation of MdWRKY9 regulates apple fruit ripening through interaction with MdERF5L.Horticulture research · 2025Article
- Comparative genomic analyses reveal different genetic basis of two types of fruit in Maloideae.Nature communications · 2025Article
- Melatonin suppresses ethylene biosynthesis by inhibiting transcription factor MdREM10 during apple fruit ripening.Horticulture research · 2025Article
- The transcription factor PbbHLH164 is destabilized by PbRAD23C/D.1 and mediates ethylene biosynthesis during pear fruit ripening.Journal of advanced research · 2024Article
- Auxin responsive factor MdARF17 promotes ethylene synthesis in apple fruits by activating MdERF003 expression.Plant cell reports · 2024Article
- Analysis of Ethylene Signal Regulating Sucrose Metabolism in Strawberry Fruits Based on RNA-seq.Plants (Basel, Switzerland) · 2024Article
- Nitric oxide (NO) modulates low temperature-stress signaling via S-nitrosation, a NO PTM, inducing ethylene biosynthesis inhibition leading to enhanced post-harvest shelf-life of agricultural produce.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Ethylene enhances MdMAPK3-mediated phosphorylation of MdNAC72 to promote apple fruit softening.The Plant cell · 2023Article
- Recent advances in epigenetic triggering of climacteric fruit ripening.Plant physiology · 2023Review
- Jasmonate activates a CsMPK6-CsMYC2 module that regulates the expression of β-citraurin biosynthetic genes and fruit coloration in orange (Citrus sinensis).The Plant cell · 2023Article
- Nitric Oxide Acts as an Inhibitor of Postharvest Senescence in Horticultural Products.International journal of molecular sciences · 2022Review
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9 authors.
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Abstract
Nitric oxide (NO) is known to modulate the action of several phytohormones. This includes the gaseous hormone ethylene, but the molecular mechanisms underlying the effect of NO on ethylene biosynthesis are unclear. Here, we observed a decrease in endogenous NO abundance during apple (Malus domestica) fruit development and exogenous treatment of apple fruit with a NO donor suppressed ethylene production, suggesting that NO is a ripening suppressor. Expression of the transcription factor MdERF5 was activated by NO donor treatment. NO induced the nucleocytoplasmic shuttling of MdERF5 by modulating its interaction with the protein phosphatase, MdPP2C57. MdPP2C57-induced dephosphorylation of MdERF5 at Ser260 is sufficient to promote nuclear export of MdERF5. As a consequence of this export, MdERF5 proteins in the cytoplasm interacted with and suppressed the activity of MdACO1, an enzyme that converts 1-aminocyclopropane-1-carboxylic acid (ACC) to ethylene. The NO-activated MdERF5 was observed to increase in abundance in the nucleus and bind to the promoter of the ACC synthase gene MdACS1 and directly suppress its transcription. Together, these results suggest that NO-activated nucleocytoplasmic MdERF5 suppresses the action of ethylene biosynthetic genes, thereby suppressing ethylene biosynthesis and limiting fruit ripening.
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