Evidence map›Paper›PMID 35254651›Full record

ArticleMolecular neurobiology2022

A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice.

Noelia López-Sánchez, Morgan Ramón-Landreau, Cristina Trujillo, Alberto Garrido-García, José M Frade

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Resistance of E2F4DN to p38Scientific reports · 2026
    Article
  2. Comparative gene regulatory networks modulatingmedRxiv : the preprint server for health sciences · 2024
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Noelia López-Sánchez *Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Científicas, E-28002, Madrid, Spain.ORCID http://orcid.org/0000-0003-3095-3438
Morgan Ramón-Landreau *Department of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Científicas, E-28002, Madrid, Spain.ORCID http://orcid.org/0000-0002-2672-116X
Cristina TrujilloDepartment of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Científicas, E-28002, Madrid, Spain.
Alberto Garrido-GarcíaDepartment of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Científicas, E-28002, Madrid, Spain.ORCID http://orcid.org/0000-0002-4214-1990
José M FradeDepartment of Molecular, Cellular and Developmental Neurobiology, Cajal Institute, Consejo Superior de Investigaciones Científicas, E-28002, Madrid, Spain. frade@cajal.csic.es.ORCID http://orcid.org/0000-0001-7067-2505
Consejo Superior de Investigaciones Científicas · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) has a complex etiology, which requires a multifactorial approach for an efficient treatment. We have focused on E2 factor 4 (E2F4), a transcription factor that regulates cell quiescence and tissue homeostasis, controls gene networks affected in AD, and is upregulated in the brains of Alzheimer's patients and of APP

Indexed as

Alzheimer DiseaseCognitive DysfunctionE2F4 Transcription FactorAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalMiceMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein PrecursorE2f4 protein, mouseE2F4 Transcription FactorAlzheimer’s diseaseAβ depositsE2F4 phosphorylationNeuronal tetraploidyRNA-seqY-maze

Identifiers

PMID35254651
PMCPMC9016056
OpenAlexW4220737936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.