Evidence map›Paper›PMID 35254549›Full record

ArticleClinical and experimental nephrology2022

Risks and renal outcomes of severe acute kidney injury in children with steroid-resistant nephrotic syndrome.

Sho Ishiwa, Mai Sato, Koichi Kamei, Kentaro Nishi, Toru Kanamori, Mika Okutsu, Masao Ogura, Mayumi Sako, Shuichi Ito, Yasushi Orihashi and 1 more

Abstract read
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In one paragraph

Article in Clinical and experimental nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Sho IshiwaDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Mai SatoDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Koichi KameiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Kentaro NishiDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Toru KanamoriDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Mika OkutsuDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Masao OguraDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Mayumi SakoDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Shuichi ItoDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan.
Yasushi OrihashiDivision of Clinical Research, Kitasato University Hospital, Sagamihara, Japan.
Kenji IshikuraDivision of Nephrology and Rheumatology, National Center for Child Health and Development, Tokyo, Japan. k-ishikura@umin.ac.jp.ORCID http://orcid.org/0000-0003-2692-6437
National Center For Child Health and Development · JPKitasato University Hospital · JP

Funding

Childhood-onset, rare and intractable kidney diseases in Japan, Research on rare and intractable diseases 20FC2028
6 · The paper itself

Abstract

backgroundRisks and renal outcomes of severe acute kidney injury (AKI) in children with steroid-resistant nephrotic syndrome (SRNS), particularly those who require dialysis, have not been fully explored.

methodsThis retrospective cohort study enrolled children who had been diagnosed with idiopathic nephrotic syndrome at the National Center for Child Health and Development between March 2002 and December 2018. Children with steroid-sensitive nephrotic syndrome or SRNS-related gene mutations were excluded.

resultsSixty-two children with SRNS (37 boys; median age, 3.6 years [interquartile range (IQR) 2.0-10.3]) were enrolled. Sixteen patients (25.8%) had severe AKI, including nine patients (14.5%) who received dialysis. The period from nephrotic syndrome (NS) onset to partial remission (median [IQR]) was not significantly influenced by dialysis status, but tended to be longer in the dialysis group (125 days [74-225] vs. 40 days [28-113]; p = 0.09); notably, no patient developed chronic kidney disease during the follow-up period. Infection and posterior reversible encephalopathy (PRES) were significantly associated with AKI. Patients with AKI tended to require dialysis in the presence of infection, undergo treatment with cyclosporine A, and have PRES. The period from onset of NS to AKI was significantly longer in the dialysis group (26 days [15.5-46.0] vs. 4 days [0.0-14.0]; p = 0.01).

conclusionDialysis was commonly required among children with SRNS who exhibited severe AKI. The period from onset of NS to partial remission tended to be longer in patients receiving dialysis, whereas renal prognosis was satisfactory during subsequent follow-up.

Indexed as

Acute Kidney InjuryNephrotic SyndromeChildChild, PreschoolHumansImmunosuppressive AgentsMaleRenal DialysisRetrospective StudiesSteroidsImmunosuppressive AgentsSteroidsAcute kidney injury (AKI)ChildrenDialysisSteroid-resistant nephrotic syndrome (SRNS)

Identifiers

PMID35254549
OpenAlexW4220667677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.