ReviewNatural products and bioprospecting2022
Structural derivatization strategies of natural phenols by semi-synthesis and total-synthesis.
Review in Natural products and bioprospecting, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Fatty Acids in Cancer Therapy: Chemical Conjugates, Nanocarriers, and Therapeutic Opportunities.Molecules (Basel, Switzerland) · 2026Review
- Synthetic Strategies and Biological Diversity of Biflavonoids: Current Status and Perspective.Molecules (Basel, Switzerland) · 2026Review
- Bioactive Constituents ofDrug design, development and therapy · 2026Review
- Total Syntheses of Sappanin-Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization.Chemistry, an Asian journal · 2025Article
- Advances, opportunities, and challenges in methods for interrogating the structure activity relationships of natural products.Natural product reports · 2024Review
- Synthesis and Bioevaluation of New Stable Derivatives of Chrysin-8-Pharmaceuticals (Basel, Switzerland) · 2024Article
- Split cross-coupling via Rh-catalysed activation of unstrained aryl-aryl bonds.Nature catalysis · 2024Article
- Photocatalytic Synthesis ofOrganic letters · 2022Article
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6 authors.
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Abstract
Structural derivatization of natural products has been a continuing and irreplaceable source of novel drug leads. Natural phenols are a broad category of natural products with wide pharmacological activity and have offered plenty of clinical drugs. However, the structural complexity and wide variety of natural phenols leads to the difficulty of structural derivatization. Skeleton analysis indicated most types of natural phenols can be structured by the combination and extension of three common fragments containing phenol, phenylpropanoid and benzoyl. Based on these fragments, the derivatization strategies of natural phenols were unified and comprehensively analyzed in this review. In addition to classical methods, advanced strategies with high selectivity, efficiency and practicality were emphasized. Total synthesis strategies of typical fragments such as stilbenes, chalcones and flavonoids were also covered and analyzed as the supplementary for supporting the diversity-oriented derivatization of natural phenols.
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