Evidence map›Paper›PMID 35254481›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2022

Non-prostate cancer tumours: incidence on

Elisa Perry, Arpit Talwar, Sanjana Sharma, Daisy O'Connor, Lih-Ming Wong, Kim Taubman, Tom R Sutherland

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Pooled it
  2. Application of theranostics in thyroid cancer management.The Journal of clinical endocrinology and metabolism · 2026
    Review
  3. Dual-tracer positron emission tomography-computed tomography withQuantitative imaging in medicine and surgery · 2026
    Article
  4. The value of [Quantitative imaging in medicine and surgery · 2026
    Article
  5. Utility of PSMA PET/CT for staging of favourable risk intermediate risk prostate cancer.European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Dependence of Renal Uptake on Kidney Function in [Diagnostics (Basel, Switzerland) · 2024
    Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Elisa PerryPacific Radiology, Level 1, 123 Victoria Street, Christchurch, Canterbury, New Zealand, 8013. elisa.perry@mh.org.au.ORCID 0000-0003-1649-5100
Arpit TalwarSt. Vincent's Hospital, Department of Medical Imaging, Melbourne, Victoria, Australia.
Sanjana SharmaSt. Vincent's Hospital, Department of Medical Imaging, Melbourne, Victoria, Australia.
Daisy O'ConnorPacific Radiology, Level 1, 123 Victoria Street, Christchurch, Canterbury, New Zealand, 8013.
Lih-Ming WongSt. Vincent's Hospital, Department of Urology, Melbourne, Victoria, Australia.
Kim TaubmanSt. Vincent's Hospital, Department of Medical Imaging, Melbourne, Victoria, Australia.
Tom R SutherlandSt. Vincent's Hospital, Department of Medical Imaging, Melbourne, Victoria, Australia.
St Vincent's Hospital Melbourne · AUThe University of Melbourne · AUPacific Radiology (New Zealand) · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWith increasing use of PSMA PET/CT in the staging and restaging of prostate cancer (PCa), the identification of non-prostate cancer tumours (NPCaT) has become an increasing clinical dilemma. Atypical presentations of PSMA expression in prostate cancer and expression in NPCaT are not well established. Understanding the normal and abnormal distribution of PSMA expression is essential in preparing clinically relevant reports and in guiding multidisciplinary discussion and decisions.

methodsRetrospective review of 1445 consecutive

results68/1445 patients had lesions atypical for prostate cancer metastases. These comprised 8/68 (11.8%) atypical prostate cancer metastases, 17/68 (25.0%) NPCaT, 29/68 (42.6%) indeterminate, and 14/68 (20.6%) benign. In the context of the entire cohort, these are adjusted to 8/1445 (0.6%), 17/1445 (1.2%), 29/1445 (2.0%), and 14/1445 (1.0%) respectively. With the exception of Renal Cell Carcinoma (RCC), NPCaT demonstrated no or low PSMA expression. A similar trend was also observed for indeterminate and benign lesions. Conversely, most atypical PCa metastases demonstrated intermediate or high PSMA expression.

conclusion

Indexed as

Carcinoma, Renal CellKidney NeoplasmsProstatic NeoplasmsHumansIncidenceLysineMalePositron Emission Tomography Computed TomographyUreaLysineUrea18F-DCFPyLBiochemical recurrencePET/CTProstate cancerPSMA

Identifiers

PMID35254481
PMCPMC9250467
OpenAlexW4221039844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.