Evidence map›Paper›PMID 35254469›Full record

ArticleInternational urogynecology journal2022

Tibial nerve stimulation increases vaginal blood perfusion and bone mineral density and yield load in ovariectomized rat menopause model.

Jiajie Jessica Xu, Lauren L Zimmerman, Vanessa H Soriano, Georgios Mentzelopoulos, Eric Kennedy, Elizabeth C Bottorff, Chris Stephan, Kenneth Kozloff, Maureen J Devlin, Tim M Bruns

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Article
  3. Immediate and Long-Term Effects of Tibial Nerve Stimulation on the Sexual Behavior of Female Rats.Neuromodulation : journal of the International Neuromodulation Society · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jiajie Jessica XuUnit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA. jjxu@illinois.edu.
Lauren L ZimmermanBiointerfaces Institute, University of Michigan, MI, Ann Arbor, USA.
Vanessa H SorianoBiointerfaces Institute, University of Michigan, MI, Ann Arbor, USA.
Georgios MentzelopoulosBiointerfaces Institute, University of Michigan, MI, Ann Arbor, USA.
Eric KennedyBiointerfaces Institute, University of Michigan, MI, Ann Arbor, USA.
Elizabeth C BottorffBiointerfaces Institute, University of Michigan, MI, Ann Arbor, USA.
Chris StephanDepartment of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA.
Kenneth KozloffBiomedical Engineering Department, University of Michigan, Ann Arbor, MI, USA.
Maureen J DevlinAnthropology Department, University of Michigan, Ann Arbor, MI, USA.
Tim M BrunsBiointerfaces Institute, University of Michigan, MI, Ann Arbor, USA. bruns@umich.edu.ORCID 0000-0003-1692-0541
University of Michigan · USUniversity of Illinois Urbana-Champaign · US

Funding

Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4M
NIAMS NIH HHS P30 AR069620
6 · The paper itself

Abstract

introduction and hypothesisHuman menopause transition and post-menopausal syndrome, driven by reduced ovarian activity and estrogen levels, are associated with an increased risk for symptoms including but not limited to sexual dysfunction, metabolic disease, and osteoporosis. Current treatments are limited in efficacy and may have adverse consequences, so investigation for additional treatment options is necessary. Previous studies have demonstrated that percutaneous tibial nerve stimulation (PTNS) and electro-acupuncture near the tibial nerve are minimally invasive treatments that increase vaginal blood perfusion or serum estrogen in the rat model. We hypothesized that PTNS would protect against harmful reproductive and systemic changes associated with menopause.

methodsWe examined the effects of twice-weekly PTNS (0.2 ms pulse width, 20 Hz, 2× motor threshold) under ketamine-xylazine anesthesia in ovariectomized (OVX) female Sprague-Dawley rats on menopause-associated physiological parameters including serum estradiol, body weight, blood glucose, bone health, and vaginal blood perfusion. Rats were split into three groups (n = 10 per group): (1) intact control (no stimulation), (2) OVX control (no stimulation), and (3) OVX stimulation (treatment group).

resultsPTNS did not affect serum estradiol levels, body weight, or blood glucose. PTNS transiently increased vaginal blood perfusion during stimulation for up to 5 weeks after OVX and increased areal bone mineral density and yield load of the right femur (side of stimulation) compared to the unstimulated OVX control.

conclusionsPTNS may ameliorate some symptoms associated with menopause. Additional studies to elucidate the full potential of PTNS on menopause-associated symptoms under different experimental conditions are warranted.

Indexed as

Blood GlucoseBone DensityAnimalsBody WeightEstradiolEstrogensFemaleHumansMenopauseOvariectomyPerfusionRatsRats, Sprague-DawleyTibial NerveBlood GlucoseEstradiolEstrogensBone mineral densityElectrical stimulationMenopauseNeuromodulationTibial nerveVaginal blood perfusion

Identifiers

PMID35254469
PMCPMC12880576
OpenAlexW4221084944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.