ArticleCerebral cortex (New York, N.Y. : 1991)2023
A connectome-based neuromarker of nonverbal number acuity and arithmetic skills.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Neural Representation Precision of Distance Predicts Children's Arithmetic Performance.Human brain mapping · 2025Article
- Structural and transcriptional signatures of arithmetic abilities in children.NPJ science of learning · 2024Article
- Inter-individual, hemispheric and sex variability of brain activations during numerosity processing.Brain structure & function · 2024Article
- The neural correlates of individual differences in numerosity perception: A voxel-based morphometry study.iScience · 2023Article
- Multivariate resting-state functional connectomes predict and characterize obesity phenotypes.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The approximate number system (ANS) is vital for survival and reproduction in animals and is crucial for constructing abstract mathematical abilities in humans. Most previous neuroimaging studies focused on identifying discrete brain regions responsible for the ANS and characterizing their functions in numerosity perception. However, a neuromarker to characterize an individual's ANS acuity is lacking, especially one based on whole-brain functional connectivity (FC). Here, based on the resting-state functional magnetic resonance imaging (rs-fMRI) data obtained from a large sample, we identified a distributed brain network (i.e. a numerosity network) using a connectome-based predictive modeling (CPM) analysis. The summed FC strength within the numerosity network reliably predicted individual differences in ANS acuity regarding behavior, as measured using a nonsymbolic number-comparison task. Furthermore, in an independent dataset of the Human Connectome Project (HCP), we found that the summed FC strength within the numerosity network also specifically predicted individual differences in arithmetic skills, but not domain-general cognitive abilities. Therefore, our findings revealed that the identified numerosity network could serve as an applicable neuroimaging-based biomarker of nonverbal number acuity and arithmetic skills.
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Registered trials
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