Evidence map›Paper›PMID 35254315›Full record

ArticleJournal of synchrotron radiation2022

A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale.

Maksim A Yakovlev, Daniel J Vanselow, Mee Siing Ngu, Carolyn R Zaino, Spencer R Katz, Yifu Ding, Dula Parkinson, Steve Yuxin Wang, Khai Chung Ang, Patrick La Riviere and 1 more

Abstract read
In one paragraph

Article in Journal of synchrotron radiation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maksim A YakovlevDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0003-1846-3751
Daniel J VanselowDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-9221-8634
Mee Siing NguDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-7638-4659
Carolyn R ZainoDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-4383-6292
Spencer R KatzDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-5586-3562
Yifu DingDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-4629-5858
Dula ParkinsonAdvanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California, USA.ORCID 0000-0002-1817-0716
Steve Yuxin WangMobile Imaging Innovations, Inc., Palatine, Illinois, USA.
Khai Chung AngDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0001-7695-9953
Patrick La RiviereDepartment of Radiology, The University of Chicago, Chicago, USA.ORCID 0000-0003-3415-9864
Keith C ChengDepartment of Pathology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-5350-5825

Funding

Groundwork for a Synchrotron MicroCT Imaging Resource for Biology (SMIRB)R24OD018559 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHENG, KEITH CHI · 2015 to 2022
$6.4M
Building a Wide-field, High-resolution Histotomography Resource for BiologyR24OD035407 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Keith Chi Cheng · 2024 to 2026
$2.8M
NIH HHS R24 OD018559NIH HHS R24 OD035407NIH HHS R24OD18559
6 · The paper itself

Abstract

Ideal three-dimensional imaging of complex samples made up of micron-scale structures extending over mm to cm, such as biological tissues, requires both wide field of view and high resolution. For existing optics and detectors used for micro-CT (computed tomography) imaging, sub-micron pixel resolution can only be achieved for fields of view of <2 mm. This article presents a unique detector system with a 6 mm field-of-view image circle and 0.5 µm pixel size that can be used in micro-CT units utilizing both synchrotron and commercial X-ray sources. A resolution-test pattern with linear microstructures and whole adult Daphnia magna were imaged at beamline 8.3.2 of the Berkeley Advanced Light Source. Volumes of 10000 × 10000 × 7096 isotropic 0.5 µm voxels were reconstructed over a 5.0 mm × 3.5 mm field of view. Measurements in the projection domain confirmed a 0.90 µm measured spatial resolution that is largely Nyquist-limited. This unprecedented combination of field of view and resolution dramatically reduces the need for sectional scans and computational stitching for large samples, ultimately offering the means to elucidate changes in tissue and cellular morphology in the context of larger, whole, intact model organisms and specimens. This system is also anticipated to benefit micro-CT imaging in materials science, microelectronics, agricultural science and biomedical engineering.

Indexed as

Imaging, Three-DimensionalSynchrotronsX-Ray MicrotomographyX-Rayshigh resolutionhistotomographylarge field of viewsynchrotron micro-CTX-ray optics

Identifiers

PMID35254315
PMCPMC8900834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.