ArticleeLife2022
Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of wearable activity trackers on physical activity among adolescents in school-based settings: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Alzheimer Disease and Epilepsy: A Mendelian Randomization Study.Neurology · 2023Pooled it
- Development and validation of a predictive model for hypothalamic obesity following craniopharyngioma resection.BMC endocrine disorders · 2026Article
- Higher BMI might increase risk of ankle-foot sprains: A mendelian randomization study.Sports medicine and health science · 2026Article
- Multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) to understand how obesity risk varies according to multiple lifestyle behavior recommendations.International journal of obesity (2005) · 2026Article
- Weight trajectories and obesity onset between 17 and 60 years of age, and cause-specific mortality: the Obesity and Disease Development Sweden (ODDS) pooled cohort study.EClinicalMedicine · 2026Article
- Bidirectional associations between smart device use and body mass index among children aged 3 to 5 years: a longitudinal study.The international journal of behavioral nutrition and physical activity · 2026Article
- Impact of mental health distress on preconception health.Intelligent hospital · 2025Article
- Correlates of physical activity among rural Australian cancer survivors: a cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- A focusing framework for testing bi-directional causal effects in Mendelian randomization.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- Analysis of Physical Activity Using Wearable Health Technology in US Adults Enrolled in the All of Us Research Program: Multiyear Observational Study.Journal of medical Internet research · 2024Observational
- Article
- Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer: A bidirectional Mendelian randomization study.World journal of clinical cases · 2024Article
- The effect of physical activity intervention on blood pressure in 18 low and middle-income countries: a systematic review and meta-analysis of randomized controlled trials.Clinical hypertension · 2024Article
- Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis.International journal of epidemiology · 2024Article
- Association of daily sitting time and leisure-time physical activity with body fat among U.S. adults.Journal of sport and health science · 2024Article
- Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium.European heart journal · 2024Article
- Trajectories of physical activity from mid to older age in women: 21 years of data from the Australian Longitudinal Study on Women's Health.The international journal of behavioral nutrition and physical activity · 2024Article
- Exploring the genetic causal relationship between physical activity and migraine in European population based on Mendelian randomization analysis.Frontiers in neurology · 2024Article
- Sedentary behavior, physical activity, sleep duration and obesity risk: Mendelian randomization study.PloS one · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical inactivity and increased sedentary time are associated with excess weight gain in observational studies. However, some longitudinal studies indicate reverse causality where weight gain leads to physical inactivity and increased sedentary time. As observational studies suffer from reverse causality, it is challenging to assess the true causal directions. Here, we assess the bidirectional causality between physical inactivity, sedentary time, and adiposity by bidirectional Mendelian randomization analysis. We used results from genome-wide association studies for accelerometer-based physical activity and sedentary time in 91,105 individuals and for body mass index (BMI) in 806,834 individuals. We implemented Mendelian randomization using CAUSE method that accounts for pleiotropy and sample overlap using full genome-wide data. We also applied inverse variance-weighted, MR-Egger, weighted median, and weighted mode methods using genome-wide significant variants only. We found evidence of bidirectional causality between sedentary time and BMI: longer sedentary time was causal for higher BMI [beta (95% CI) from CAUSE method: 0.11 (0.02, 0.2), p = 0.02], and higher BMI was causal for longer sedentary time (0.13 (0.08, 0.17), p = 6.3 x 10
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