ArticleeLife2022
Large-scale orientational order in bacterial colonies during inward growth.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- A minimal mechanically consistent model of smoothly dividing disk-shaped cells.NPJ systems biology and applications · 2026Article
- Dissecting the physics of bacterial biofilms with agent-based simulations.Current opinion in solid state & materials science · 2025Article
- Segmentation of dense and multi-species bacterial colonies using models trained on synthetic microscopy images.PLoS computational biology · 2025Article
- Integer topological defects offer a methodology to quantify and classify active cell monolayers.Nature communications · 2025Article
- Article
- Matrix-producing cells' orientation order facilitates Bacillus subtilis biofilm self-healing.Archives of microbiology · 2024Article
- The biophysical basis of bacterial colony growth.Nature physics · 2024Article
- Optogenetic Control of Bacterial Cell-Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms.Soft matter · 2024Article
- Cellular arrangement impacts metabolic activity and antibiotic tolerance in Pseudomonas aeruginosa biofilms.PLoS biology · 2024Article
- Spontaneous flows and quantum analogies in heterogeneous active nematic films.Communications physics · 2024Article
- Biofilms as self-shaping growing nematics.Nature physics · 2023Article
- Cell arrangement impacts metabolic activity and antibiotic tolerance inbioRxiv : the preprint server for biology · 2023Article
- Molecular-scale substrate anisotropy, crowding and division drive collective behaviours in cell monolayers.Journal of the Royal Society, Interface · 2023Article
- Vertical growth dynamics of biofilms.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Scattering angle resolved optical coherence tomography measures morphological changes inJournal of biomedical optics · 2022Article
- Stress anisotropy in confined populations of growing rods.Journal of the Royal Society, Interface · 2022Article
- Morphological instability and roughening of growing 3D bacterial colonies.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanical forces drive a reorientation cascade leading to biofilm self-patterning.Nature communications · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During colony growth, complex interactions regulate the bacterial orientation, leading to the formation of large-scale ordered structures, including topological defects, microdomains, and branches. These structures may benefit bacterial strains, providing invasive advantages during colonization. Active matter dynamics of growing colonies drives the emergence of these ordered structures. However, additional biomechanical factors also play a significant role during this process. Here, we show that the velocity profile of growing colonies creates strong radial orientation during inward growth when crowded populations invade a closed area. During this process, growth geometry sets virtual confinement and dictates the velocity profile. Herein, flow-induced alignment and torque balance on the rod-shaped bacteria result in a new stable orientational equilibrium in the radial direction. Our analysis revealed that the dynamics of these radially oriented structures, also known as aster defects, depend on bacterial length and can promote the survival of the longest bacteria around localized nutritional hotspots. The present results indicate a new mechanism underlying structural order and provide mechanistic insights into the dynamics of bacterial growth on complex surfaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.