Evidence map›Paper›PMID 35254100›Full record

ArticleApplied and environmental microbiology2022

Role of the Transcriptional Regulator ArgR in the Connection between Arginine Metabolism and c-di-GMP Signaling in Pseudomonas putida.

Laura Barrientos-Moreno, María Antonia Molina-Henares, María Isabel Ramos-González, Manuel Espinosa-Urgel

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Arginine at the host-pathogen interface.Infection and immunity · 2025
    Review
  3. Article
  4. Article
  5. Exploring the Metabolic Response of Pseudomonas putida to L-arginine.Advances in experimental medicine and biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Gene expression reprogramming ofMicrobiology (Reading, England) · 2024
    Article
  10. Article
  11. Nutrient Sensing and Biofilm Modulation: The Example of L-arginine inInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Laura Barrientos-MorenoDepartment of Environmental Protection, Estación Experimental del Zaidín, CSIC, Granada, Spain.
María Antonia Molina-HenaresDepartment of Environmental Protection, Estación Experimental del Zaidín, CSIC, Granada, Spain.
María Isabel Ramos-GonzálezDepartment of Environmental Protection, Estación Experimental del Zaidín, CSIC, Granada, Spain.ORCID 0000-0001-8380-807X
Manuel Espinosa-UrgelDepartment of Environmental Protection, Estación Experimental del Zaidín, CSIC, Granada, Spain.ORCID 0000-0002-6862-0682
Estación Experimental del Zaidín · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The second messenger cyclic di-GMP (c-di-GMP) is a key molecule that controls different physiological and behavioral processes in many bacteria, including motile-to-sessile lifestyle transitions. Although the external stimuli that modulate cellular c-di-GMP contents are not fully characterized, there is growing evidence that certain amino acids act as environmental cues for c-di-GMP turnover. In the plant-beneficial bacterium Pseudomonas putida KT2440, both arginine biosynthesis and uptake influence second messenger contents and the associated phenotypes. To further understand this connection, we have analyzed the role of ArgR, which in different bacteria is the master transcriptional regulator of arginine metabolism but had not been characterized in P. putida. The results show that ArgR controls arginine biosynthesis and transport, and an

Indexed as

Pseudomonas putidaArginineBacterial ProteinsBiofilmsCyclic GMPGene Expression Regulation, BacterialArginineBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMPamino acid biosynthesisamino acid transportarginine synthesisbiofilmc-di-GMPcell signalinggene regulationmetabolismPseudomonassecond messengertransport

Identifiers

PMID35254100
PMCPMC9004404
OpenAlexW4220747147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.