ArticleCerebral cortex (New York, N.Y. : 1991)2022
Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of the Hayling and Brixton Tests for Detecting Dementia, Progressive Cognitive Decline, and Mild Cognitive Impairment in Middle to Older Aged Adults: A Systematic Review and Meta-analysis.Neuropsychology review · 2026Pooled it
- Diagnostic utility of electrophysiological markers for early and differential diagnosis of Alzheimer's, Frontotemporal, and Lewy Body dementias: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- Electrophysiological alterations during action semantic processing in Parkinson's disease.Neurobiology of aging · 2024Article
- Neurocognitive correlates of semantic memory navigation in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds.Scientific data · 2023Article
- The neurocognitive impact of loneliness and social networks on social adaptation.Scientific reports · 2023Article
- Social concepts and the cerebellum: behavioural and functional connectivity signatures in cerebellar ataxic patients.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Emotional descriptions increase accidental harm punishment and its cortico-limbic signatures during moral judgment in autism.Scientific reports · 2023Article
- Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.Journal of cognition · 2023Article
- Genuine high-order interactions in brain networks and neurodegeneration.Neurobiology of disease · 2022Article
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Abstract
backgroundProcessing of linguistic negation has been associated to inhibitory brain mechanisms. However, no study has tapped this link via multimodal measures in patients with core inhibitory alterations, a critical approach to reveal direct neural correlates and potential disease markers.
methodsHere we examined oscillatory, neuroanatomical, and functional connectivity signatures of a recently reported Go/No-go negation task in healthy controls and behavioral variant frontotemporal dementia (bvFTD) patients, typified by primary and generalized inhibitory disruptions. To test for specificity, we also recruited persons with Alzheimer's disease (AD), a disease involving frequent but nonprimary inhibitory deficits.
resultsIn controls, negative sentences in the No-go condition distinctly involved frontocentral delta (2-3 Hz) suppression, a canonical inhibitory marker. In bvFTD patients, this modulation was selectively abolished and significantly correlated with the volume and functional connectivity of regions supporting inhibition (e.g. precentral gyrus, caudate nucleus, and cerebellum). Such canonical delta suppression was preserved in the AD group and associated with widespread anatomo-functional patterns across non-inhibitory regions. DISCUSSION: These findings suggest that negation hinges on the integrity and interaction of spatiotemporal inhibitory mechanisms. Moreover, our results reveal potential neurocognitive markers of bvFTD, opening a new agenda at the crossing of cognitive neuroscience and behavioral neurology.
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