Evidence map›Paper›PMID 35253643›Full record

ArticleeLife2022

How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.

Kerry Marie Goodman, Phinikoula S Katsamba, Rotem Rubinstein, Göran Ahlsén, Fabiana Bahna, Seetha Mannepalli, Hanbin Dan, Rosemary V Sampogna, Lawrence Shapiro, Barry Honig

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions.Advances in experimental medicine and biology · 2026
    Review
  3. SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Clustered protocadherinProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Visualization ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Article
  17. The physiology of alternative splicing.Nature reviews. Molecular cell biology · 2023
    Review
  18. Article
  19. On the formation of ordered protein assemblies in cell-cell interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kerry Marie Goodman *Zuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.ORCID 0000-0003-2063-5823
Phinikoula S Katsamba *Zuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.ORCID 0000-0003-3981-1604
Rotem RubinsteinSchool of Neurobiology, Biochemistry and Biophysics, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-3657-5984
Göran AhlsénZuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.
Fabiana BahnaZuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.
Seetha MannepalliZuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.
Hanbin DanDepartment of Medicine, Division of Nephrology, Columbia University, New York, United States.
Rosemary V SampognaDepartment of Medicine, Division of Nephrology, Columbia University, New York, United States.ORCID 0000-0002-1279-4552
Lawrence ShapiroZuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.ORCID 0000-0001-9943-8819
Barry HonigZuckerman Mind, Brain and Behavior Institute, Columbia University, New York, United States.ORCID 0000-0002-2480-6696

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
The structural basis of cis and trans protocadherin interactionsR01MH114817 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2017 to 2021
$2.4M
Circadian clock regulation of branching morphogenesis during kidney developmentR01DK106548 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SAMPOGNA, ROSEMARY V · 2016 to 2020
$1.8M
NIDDK NIH HHS R01 DK106548NIGMS NIH HHS P41 GM103403NIMH NIH HHS R01 MH114817
6 · The paper itself

Abstract

The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alternating

Indexed as

CadherinsProtocadherinsCell CommunicationNeuronsProtein IsoformsCadherinsProtein IsoformsProtocadherinscis interactionscrystal structuremolecular biophysicsmouseneuronal self-avoidanceneuroscienceprotocadherinsself-recognitionstructural biologytrans interactions

Identifiers

PMID35253643
PMCPMC8901172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.