ArticleJournal of the American Heart Association2022
Relationship of Quantitative Retinal Capillary Network and Myocardial Remodeling in Systemic Hypertension.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06098300 (Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension - a Pilot Study), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Change in Blood Pressure on Retinal Capillary Rarefaction in Patients With Arterial Hypertension - a Pilot Study
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Retinal layer thickness as a potential marker for future cardiovascular events - a UK Biobank cohort study using optical coherence tomography.Journal of neurology · 2026Article
- Analysis of factors influencing retinal thickness in chronic obstructive pulmonary disease and hypertension: a cross-sectional study in a community-dwelling middle-aged and elderly population.Frontiers in medicine · 2026Article
- Evaluating the effect of systemic hypertension on retinal, optic nerve head microvasculature and field of vision using optical coherence tomography angiography and visual field analyzer.BMC ophthalmology · 2025Observational
- Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- The Use of Retinal Imaging Including Fundoscopy, OCT, and OCTA for Cardiovascular Risk Stratification and the Detection of Subclinical Atherosclerosis.Current atherosclerosis reports · 2025Review
- Research advances on artificial intelligence assisted diagnosis and risk assessment in cardiovascular disease using retinal imaging.Frontiers in cardiovascular medicine · 2025Review
- Perifoveal Exudative Vascular Anomalous Complex (PEVAC): Retinal Vascular Density Findings.Journal of clinical medicine · 2024Article
- Retinal Imaging-Based Oculomics: Artificial Intelligence as a Tool in the Diagnosis of Cardiovascular and Metabolic Diseases.Biomedicines · 2024Review
- Comparing Optical Coherence Tomography Angiography Metrics in Healthy Chinese and Caucasian Adults.Journal of personalized medicine · 2024Article
- Ocular microvascular alteration in patients with myocardial infarction-a new OCTA study.Scientific reports · 2024Article
- The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease.Journal of clinical medicine · 2024Review
- Assessment of Retinal Microangiopathy in Patients with Balkan Endemic Nephropathy Using Optical Coherence Tomography Angiography-A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Article
- Retinal Findings and Cardiovascular Risk: Prognostic Conditions, Novel Biomarkers, and Emerging Image Analysis Techniques.Journal of personalized medicine · 2023Review
- Prevalence of venous loops and association with retinal ischemia in diabetic retinopathy using widefield swept-source OCT angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Correlation Between Coronary and Retinal Microangiopathy in Patients With STEMI.Translational vision science & technology · 2023Article
- The association between retinal microvasculature derived from optical coherence tomography angiography and systemic factors in type 2 diabetics.Frontiers in medicine · 2023Article
- Retinal and Choroidal Thinning-A Predictor of Coronary Artery Occlusion?Diagnostics (Basel, Switzerland) · 2022Article
- Cross-modality Labeling Enables Noninvasive Capillary Quantification as a Sensitive Biomarker for Assessing Cardiovascular Risk.Ophthalmology scienceArticle
- Optical coherence tomography angiography quantitative analysis and 10-year cardiovascular disease risk in the general population.Taiwan journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background This study examined the associations between quantitative optical coherence tomography angiography (OCTA) parameters and myocardial abnormalities as documented on cardiovascular magnetic resonance imaging in patients with systemic hypertension. Methods and Results We conducted a cross-sectional study of 118 adults with hypertension (197 eyes). Patients underwent cardiovascular magnetic resonance imaging and OCTA (PLEX Elite 9000, Carl Zeiss Meditec). Associations between OCTA parameters (superficial and deep retinal capillary density) and adverse cardiac remodeling (left ventricular mass, remodeling index, interstitial fibrosis, global longitudinal strain, and presence of left ventricular hypertrophy) were studied using multivariable linear regression analysis with generalized estimating equations. Of the 118 patients with hypertension enrolled (65% men; median [interquartile range] age, 59 [13] years), 29% had left ventricular hypertrophy. After adjusting for age, sex, systolic blood pressure, diabetes, and signal strength of OCTA scans, patients with lower superficial capillary density had significantly higher left ventricular mass (β=-0.150; 95% CI, -0.290 to -0.010), higher interstitial volume (β=-0.270; 95% CI, -0.535 to -0.0015), and worse global longitudinal strain (β=-0.109; 95% CI, -0.187 to -0.032). Lower superficial capillary density was found in patients with hypertension with replacement fibrosis versus no replacement fibrosis (16.53±0.64 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.