ArticleJournal of the American Heart Association2022
Virtual Transcatheter Interventions for Peripheral Pulmonary Artery Stenosis in Williams and Alagille Syndromes.
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- On the accuracy of implicit neural representations for cardiovascular anatomies and hemodynamic fields.Computers in biology and medicine · 2026Article
- On the performance of multi-fidelity and reduced-dimensional neural emulators for inference of physiological boundary conditions.Computers in biology and medicine · 2026Article
- Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations.Journal of biomechanical engineering · 2025Article
- Application feasibility of virtual models and computational fluid dynamics for the planning and evaluation of aortic repair surgery for Williams syndrome.Journal of cardiothoracic surgery · 2025Article
- DIRECT MEDICAL IMAGE TO SIMULATION USING AUTO-SEGMENTATION AND POINT CLOUD-BASED CFD.Advances in computational science and engineering · 2025Article
- Deforming Patient-Specific Models of Vascular Anatomies to Represent Stent Implantation via Extended Position Based Dynamics.Cardiovascular engineering and technology · 2024Article
- FSGe: A fast and strongly-coupled 3D fluid-solid-growth interaction method.Computer methods in applied mechanics and engineering · 2024Article
- Clinical Care for Cardiovascular Disease in Patients With Williams-Beuren Syndrome.Journal of the American Heart Association · 2024Review
- Complex Pulmonary Artery Rehabilitation in Children with Alagille Syndrome: An Early Single-Center Experience of a Successful Collaborative Work.Journal of cardiovascular development and disease · 2024Article
- A probabilistic neural twin for treatment planning in peripheral pulmonary artery stenosis.International journal for numerical methods in biomedical engineering · 2024Article
- Non-invasive Estimation of Pressure Drop Across Aortic Coarctations: Validation of 0D and 3D Computational Models with In Vivo Measurements.Annals of biomedical engineering · 2024Article
- A Modular Framework for Implicit 3D-0D Coupling in Cardiac Mechanics.Computer methods in applied mechanics and engineering · 2024Article
- A computational growth and remodeling framework for adaptive and maladaptive pulmonary arterial hemodynamics.Biomechanics and modeling in mechanobiology · 2023Article
- Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model.Scientific reports · 2023Article
- A Computational Growth and Remodeling Framework for Adaptive and Maladaptive Pulmonary Arterial Hemodynamics.bioRxiv : the preprint server for biology · 2023Article
- svMorph: Interactive Geometry-Editing Tools for Virtual Patient-Specific Vascular Anatomies.Journal of biomechanical engineering · 2023Article
- Recent advances in quantifying the mechanobiology of cardiac development via computational modeling.Current opinion in biomedical engineering · 2023Article
- Beyond CFD: Emerging methodologies for predictive simulation in cardiovascular health and disease.Biophysics reviews · 2023Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Background Despite favorable outcomes of surgical pulmonary artery (PA) reconstruction, isolated proximal stenting of the central PAs is common clinical practice for patients with peripheral PA stenosis in association with Williams and Alagille syndromes. Given the technical challenges of PA reconstruction and the morbidities associated with transcatheter interventions, the hemodynamic consequences of all treatment strategies must be rigorously assessed. Our study aims to model, assess, and predict hemodynamic outcomes of transcatheter interventions in these patients. Methods and Results Isolated proximal and "extensive" interventions (stenting and/or balloon angioplasty of proximal and lobar vessels) were performed in silico on 6 patient-specific PA models. Autoregulatory adaptation of the cardiac output and downstream arterial resistance was modeled in response to intervention-induced hemodynamic perturbations. Postintervention computational fluid dynamics predictions were validated in 2 stented patients and quantitatively assessed in 4 surgical patients. Our computational methods accurately predicted postinterventional PA pressures, the primary indicators of success for treatment of peripheral PA stenosis. Proximal and extensive treatment achieved median reductions of 14% and 40% in main PA systolic pressure, 27% and 56% in pulmonary vascular resistance, and 10% and 45% in right ventricular stroke work, respectively. Conclusions In patients with Williams and Alagille syndromes, extensive transcatheter intervention is required to sufficiently reduce PA pressures and right ventricular stroke work. Transcatheter therapy was shown to be ineffective for long-segment stenosis and pales hemodynamically in comparison with published outcomes of surgical reconstruction. Regardless of the chosen strategy, a virtual treatment planning platform could identify lesions most critical for optimizing right ventricular afterload.
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