Evidence map›Paper›PMID 35253265›Full record

Trial reportStatistics in medicine2022

Model-assisted analyses of longitudinal, ordinal outcomes with absorbing states.

Jonathan S Schildcrout, Frank E Harrell, Patrick J Heagerty, Sebastien Haneuse, Chiara Di Gravio, Shawn P Garbett, Paul J Rathouz, Bryan E Shepherd

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Statistics in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Optimizing endpoints in early phase clinical trials of acute respiratory distress syndrome.American journal of respiratory and critical care medicine · 2026
    Article
  3. Article
  4. A New Generation of Clinical Endpoints for Critical Care Trials.American journal of respiratory and critical care medicine · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jonathan S SchildcroutDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-2276-2551
Frank E HarrellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Patrick J HeagertyDepartment of Biostatistics, University of Washington School of Public Health, Seattle, Washington, USA.
Sebastien HaneuseDepartment of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Chiara Di GravioDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shawn P GarbettDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Paul J RathouzDepartment of Population Health, Dell Medical Center, University of Texas, Austin, Texas, USA.
Bryan E ShepherdDepartment of Biostatistics, University of Washington School of Public Health, Seattle, Washington, USA.
Vanderbilt University Medical Center · USUniversity of Washington · USHarvard University · USTexas Medical Center · US

Funding

ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7M
Outcome Dependent Sampling Studies of Longitudinal Data: Design and AnalysisR01HL094786 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jonathan Scott Schildcrout · 2009 to 2026
$6.1M
Statistical Methods for Ordinal Variables in HIV/AIDS StudiesR01AI093234 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Chun Li, Bryan Earl Shepherd · 2011 to 2026
$4.9M
NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS OT2HL156812NHLBI NIH HHS R01 HL094786NHLBI NIH HHS R01-HL094786NIAID NIH HHS R01 AI093234NIAID NIH HHS R01-AI093234
6 · The paper itself

Abstract

Studies of critically ill, hospitalized patients often follow participants and characterize daily health status using an ordinal outcome variable. Statistically, longitudinal proportional odds models are a natural choice in these settings since such models can parsimoniously summarize differences across patient groups and over time. However, when one or more of the outcome states is absorbing, the proportional odds assumption for the follow-up time parameter will likely be violated, and more flexible longitudinal models are needed. Motivated by the VIOLET Study (Ginde et al), a parallel-arm, randomized clinical trial of Vitamin

Indexed as

BiometryCritical IllnessHumansLikelihood FunctionsLongitudinal StudiesOdds Ratioabsorbing statelongitudinal datamarginalized modelsordinal responsespartial proportional oddsproportional oddsrandomized clinical trial

Identifiers

PMID35253265
PMCPMC9232888
OpenAlexW4220949709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.