Evidence map›Paper›PMID 35253228›Full record

ArticleClinical cardiology2022

Sex differences in treatment and outcomes of patients with in-hospital ST-elevation myocardial infarction.

Julia Stehli, Diem Dinh, Misha Dagan, Ron Dick, Stephanie Oxley, Angela Brennan, Jeffrey Lefkovits, Stephen J Duffy, Sarah Zaman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Prospective comparison of temporal changes in myocardial function in women with Takotsubo versus anterior STEMI.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Observational
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Julia StehliNursing and Health Sciences, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-3089-1062
Diem DinhSchool of Public Health and Preventive Medicine, Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, Victoria, Australia.
Misha DaganDepartment of General Medicine, The Alfred Hospital, Melbourne, Victoria, Australia.
Ron DickEpworth HealthCare, Richmond, Victoria, Australia.
Stephanie OxleyEpworth HealthCare, Richmond, Victoria, Australia.
Angela BrennanSchool of Public Health and Preventive Medicine, Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, Victoria, Australia.
Jeffrey LefkovitsNursing and Health Sciences, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia.
Stephen J DuffyNursing and Health Sciences, Faculty of Medicine, Monash University, Melbourne, Victoria, Australia.
Sarah ZamanSchool of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0001-6289-583X
Epworth Hospital · AUMonash University · AUThe Alfred Hospital · AUThe Royal Melbourne Hospital · AUThe University of Sydney · AU

Funding

Epworth Medical Foundation N/A
6 · The paper itself

Abstract

background and hypothesisTwo cohorts face high mortality after ST-elevation myocardial infarction (STEMI): females and patients with in-hospital STEMI. The aim of this study was to evaluate sex differences in ischemic times and outcomes of in-hospital STEMI patients.

methodsConsecutive STEMI patients treated with percutaneous coronary intervention (PCI) were prospectively recruited from 30 hospitals into the Victorian Cardiac Outcomes Registry (2013-2018). Sex discrepancies within in-hospital STEMIs were compared with out-of-hospital STEMIs. The primary endpoint was 12-month all-cause mortality. Secondary endpoints included symptom-to-device (STD) time and 30-day major adverse cardiovascular events (MACE). To investigate the relationship between sex and 12-month mortality for in-hospital versus out-of-hospital STEMIs, an interaction analysis was included in the multivariable models.

resultsA total of 7493 STEMI patients underwent PCI of which 494 (6.6%) occurred in-hospital. In-hospital versus out-of-hospital STEMIs comprised 31.9% and 19.9% females, respectively. Female in-hospital STEMIs were older (69.5 vs. 65.9 years, p = .003) with longer adjusted geometric mean STD times (104.6 vs. 94.3 min, p < .001) than men. Female versus male in-hospital STEMIs had no difference in 12-month mortality (27.1% vs. 20.3%, p = .92) and MACE (22.8% vs. 19.3%, p = .87). Female sex was not independently associated with 12-month mortality for in-hospital STEMIs which was consistent across the STEMI cohort (OR: 1.26, 95% CI: 0.94-1.70, p = .13).

conclusionsIn-hospital STEMIs are more frequent in females relative to out-of-hospital STEMIs. Despite already being under medical care, females with in-hospital STEMIs experienced a 10-min mean excess in STD time compared with males, after adjustment for confounders. Adjusted 12-month mortality and MACE were similar to males.

Indexed as

ST Elevation Myocardial InfarctionFemaleHospital MortalityHospitalsHumansMalePercutaneous Coronary InterventionSex FactorsTime FactorsTreatment Outcomefemalein-hospital STEMIsex discrepanciessymptom-to-device timewomen

Identifiers

PMID35253228
PMCPMC9019891
OpenAlexW4220751031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.