Evidence map›Paper›PMID 35252958›Full record

ReviewFrontiers in digital health2022

Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence.

Mônica Villa Nova, Tzu Ping Lin, Saeed Shanehsazzadeh, Kinjal Jain, Samuel Cheng Yong Ng, Richard Wacker, Karim Chichakly, Matthias G Wacker

Abstract readReview
In one paragraph

Review in Frontiers in digital health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
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  4. Article
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  6. Review
  7. Article
  8. Advancements in Nanoparticle Characterization.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mônica Villa NovaDepartment of Pharmacy, State University of Maringá, Maringá, Brazil.
Tzu Ping LinWacker Research Lab, Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Saeed ShanehsazzadehBiological Resources Imaging Laboratory, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia.
Kinjal JainWacker Research Lab, Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Samuel Cheng Yong NgWacker Research Lab, Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Richard WackerYellowMap AG, Karlsruhe, Germany.
Karim Chichaklyisee systems, Lebanon, NH, United States.
Matthias G WackerWacker Research Lab, Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Today, a growing number of computational aids and simulations are shaping model-informed drug development. Artificial intelligence, a family of self-learning algorithms, is only the latest emerging trend applied by academic researchers and the pharmaceutical industry. Nanomedicine successfully conquered several niche markets and offers a wide variety of innovative drug delivery strategies. Still, only a small number of patients benefit from these advanced treatments, and the number of data sources is very limited. As a consequence, "big data" approaches are not always feasible and smart combinations of human and artificial intelligence define the research landscape. These methodologies will potentially transform the future of nanomedicine and define new challenges and limitations of machine learning in their development. In our review, we present an overview of modeling and artificial intelligence applications in the development and manufacture of nanomedicines. Also, we elucidate the role of each method as a facilitator of breakthroughs and highlight important limitations.

Indexed as

artificial intelligence - AIdesign of experiment - DoEdrug deliveryliposomesmachine learning - MLnanomedicinenanoparticlesPBPK/PKPD modeling and simulations

Identifiers

PMID35252958
PMCPMC8894322

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.