Evidence map›Paper›PMID 35252944›Full record

ArticleThe Lancet regional health. Europe2022

Recent historic increase of infant mortality in France: A time-series analysis, 2001 to 2019.

Nhung T H Trinh, Sophie de Visme, Jérémie F Cohen, Tim Bruckner, Nathalie Lelong, Pauline Adnot, Jean-Christophe Rozé, Béatrice Blondel, François Goffinet, Grégoire Rey and 3 more

Abstract read
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In one paragraph

Article in The Lancet regional health. Europe, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  5. Spatial Trends in Mortality Convergence: The Cases of France, Italy, and Spain, 1975-2019.European journal of population = Revue europeenne de demographie · 2025
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  15. Evolution of the infant mortality rate: Is France peculiar?The Lancet regional health. Europe · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nhung T H TrinhCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Sophie de VismeCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Jérémie F CohenCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Tim BrucknerProgram in Public Health and Center for Population, Inequality, and Policy, University of California, Irvine, CA, USA.
Nathalie LelongCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Pauline AdnotDepartment of General Pediatrics and Pediatric Infectious Diseases, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Necker - Enfants malades, Université de Paris, Paris, France.
Jean-Christophe RozéClinical Investigation Centre, INSERM, Nantes University Hospital, CIC 1413, Nantes, France.
Béatrice BlondelCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
François GoffinetCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Grégoire ReyCenter for Epidemiology on Medical Causes of Death (CépiDc), INSERM, Le Kremlin-Bicêtre, France.
Pierre-Yves AncelCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Jennifer ZeitlinCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.
Martin ChalumeauCentre of Research in Epidemiology and Statistics (CRESS), Obstetrical, Perinatal and Pediatric Epidemiology Research Team, INSERM, Université de Paris, Maternité Port-Royal, 53 Avenue de l'Observatoire, 75014, Paris F-75004, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe infant mortality rate (IMR) serves as a key indicator of population health.

methodsWe used data from the French National Institute of Statistics and Economic Studies on births and deaths during the first year of life from 2001 to 2019 to calculate IMR aggregated by month. We ran joinpoint regressions to identify inflection points and assess the linear trend of each segment. Exploratory analyses were performed for overall IMR, as well as by age at death subgroups (early neonatal [D0-D6], late neonatal [D7-27], and post-neonatal [D28-364]), and by sex. We performed sensitivity analyses by excluding deaths at D0 and using other time-series modeling strategies.

resultsOver the 19-year study period, 53,077 infant deaths occurred, for an average IMR of 3·63/1000 (4·00 in male, 3·25 in female); 24·4% of these deaths occurred during the first day of life and 47·8% during the early neonatal period. Joinpoint analysis identified two inflection points in 2005 and 2012. The IMR decreased sharply from 2001 to 2005 (slope: -0·0167 deaths/1000 live births/month; 95%CI: -0·0219 to -0·0116) and then decreased slowly between 2005 and 2012 (slope: -0·0041; 95%CI: -0·0065 to -0·0016). From 2012 onwards, a significant increase in IMR was observed (slope: 0·0033; 95%CI: 0·0011 to 0·0056). Subgroup analyses indicated that these trends were driven notably by an increase in the early neonatal period. Sensitivity analyses provided consistent results.

interpretationThe recent historic increase in IMR since 2012 in France should prompt urgent in-depth investigation to understand the causes and prepare corrective actions.

fundingNo financial relationships with any organizations that might have an interest in the submitted work in the previous three years, no other relationships or activities that could appear to have influenced the submitted work.

Indexed as

Infant mortalityInterrupted time-series analysisJoinpoints regression

Identifiers

PMID35252944
PMCPMC8891691

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