Evidence map›Paper›PMID 35252904›Full record

ArticleSSM. Mental health2021

Internalized stigma, depressive symptoms, and the modifying role of antiretroviral therapy: A cohort study in rural Uganda.

Lisa M Bebell, Annet Kembabazi, Nicholas Musinguzi, Jeffrey N Martin, Peter W Hunt, Yap Boum, Kelli N O'Laughlin, Conrad Muzoora, Jessica E Haberer, Mwebesa Bosco Bwana and 3 more

Open access · goldAbstract read
In one paragraph

Article in SSM. Mental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Association between Internalized Stigma and Depression among People Living with HIV in Thailand.International journal of environmental research and public health · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Lisa M BebellMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Annet KembabaziCenter for Global Health, Massachusetts General Hospital, Boston, MA, USA.
Nicholas MusinguziMbarara University of Science and Technology, Mbarara, Uganda.
Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Peter W HuntDepartment of Medicine, University of California, San Francisco, CA, USA.
Yap BoumEpicentre, Paris, France.
Kelli N O'LaughlinDepartments of Emergency Medicine and Global Health, University of Washington, Seattle, WA, USA.
Conrad MuzooraMbarara University of Science and Technology, Mbarara, Uganda.
Jessica E HabererCenter for Global Health, Massachusetts General Hospital, Boston, MA, USA.
Mwebesa Bosco BwanaMbarara University of Science and Technology, Mbarara, Uganda.
David R BangsbergOregon Health & Science University-Portland State University School of Public Health, Portland, OR, USA.
Mark J SiednerMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Alexander C TsaiCenter for Global Health, Massachusetts General Hospital, Boston, MA, USA.
Harvard University · USMbarara University of Science and Technology · UGUniversity of California, San Francisco · USPortland State University · USUniversity of Washington · US

Funding

TB PREVENTION AND HIV IN THE HOMELESS--AN INTERVENTIONR01MH054907 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 1995 to 2014
$20.7M
Social Networks, HIV Stigma, and the HIV Care Cascade in Rural UgandaR01MH113494 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI TSAI, ALEXANDER C · 2017 to 2021
$3.2M
HIV Infection, Placental Inflammation, and Early Childhood Outcomes in HIV-exposed, Uninfected Infants in UgandaK23AI138856 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI BEBELL, LISA M · 2019 to 2023
$1.1M
Linking Refugees to HIV Clinical Care in UgandaK23MH108440 · NIMH · UNIVERSITY OF WASHINGTON · PI O'LAUGHLIN, KELLI NICOLE · 2016 to 2020
$990k
HIV Outcomes Research and Training in UgandaK24AA015287 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BANGSBERG, DAVID ROY · 2004 to 2008
$680k
NIAAA NIH HHS K24 AA015287NIAID NIH HHS K23 AI138856NIMH NIH HHS K23 MH108440NIMH NIH HHS R01 MH054907NIMH NIH HHS R01 MH113494
6 · The paper itself

Abstract

Depression affects over 40% of people with HIV (PHIV) in low- and middle-income countries, and over half of PHIV report HIV-related internalized stigma. However, few longitudinal studies of PHIV have examined the relationship between HIV-related stigma and depression. Data were analyzed from the 2007-15 Uganda AIDS Rural Treatment Outcomes (UARTO) Study, a cohort of 454 antiretroviral therapy (ART)-naïve PHIV (68% women) starting ART. Our primary outcome was depression symptom severity over the first two years of ART, measured using a locally adapted version of the Hopkins Symptom Checklist; our primary exposure was the 6-item Internalized AIDS-Related Stigma Scale. Both scores were measured at enrollment and at quarterly follow-up visits. We fit linear generalized estimating equations (GEE) regression models to estimate the association between stigma and depression symptom severity, adjusting for potential confounders. We included a stigma×time product term to assess the modifying effect of ART on the association between internalized stigma and depression symptom severity. UARTO participants had a median age of 32 years and median enrollment CD4 count of 217 cells/mm

Indexed as

Antiretroviral therapyDepressionDiscriminationHIVMental healthPrejudiceStigmaSub-saharan africaUganda

Identifiers

PMID35252904
PMCPMC8896824
OpenAlexW3207314033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.