ArticleSTAR protocols2022
Statistical machine learning for comparative protein dynamics with the DROIDS/maxDemon software pipeline.
Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Evolution of drug resistance drives destabilization of flap region dynamics in HIV-1 protease.Biophysical reports · 2023Article
- Persistent cross-species SARS-CoV-2 variant infectivity predicted via comparative molecular dynamics simulation.Royal Society open science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative analysis of protein structure or sequence alignments often ignores the protein dynamics and function. We offer a graphical user interface to a computing pipeline, complete with molecular visualization, enabling the biophysical simulation and statistical comparison of two-state functional protein dynamics (i.e., single unbound state vs. complex with a ligand, DNA, or protein). We utilize multi-agent machine learning classifiers to identify functionally conserved dynamic motions and compare them in genetic or drug-class variants. For complete details on the use and execution of this profile, please refer to Babbitt et al. (2020b, 2020a, 2018) and Rynkiewicz et al. (2021).
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Registered trials
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