Evidence map›Paper›PMID 35252882›Full record

ArticleSTAR protocols2022

FusionAI, a DNA-sequence-based deep learning protocol reduces the false positives of human fusion gene prediction.

Pora Kim, Hua Tan, Jiajia Liu, Himansu Kumar, Xiaobo Zhou

Abstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Characteristics of fusion genes in breast cancer.Cancer cell international · 2026
    Review
  2. Article
  3. Article
  4. Oncogenic gene fusions in cancer: from biology to therapy.Signal transduction and targeted therapy · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pora KimSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Hua TanSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Jiajia LiuSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Himansu KumarSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Xiaobo ZhouSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Funding

Functional annotation of new genes aided by deep learningR35GM138184 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KIM, PORA · 2020 to 2024
$1.7M
NIGMS NIH HHS R35 GM138184
6 · The paper itself

Abstract

Even though there were many tool developments of fusion gene prediction from NGS data, too many false positives are still an issue. Wise use of the genomic features around the fusion gene breakpoints will be helpful to identify reliable fusion genes efficiently. For this aim, we developed FusionAI, a deep learning pipeline predicting human fusion gene breakpoints from DNA sequence. FusionAI is freely available via https://compbio.uth.edu/FusionGDB2/FusionAI. For complete details on the use and execution of this protocol, please refer to Kim et al. (2021b).

Indexed as

Deep LearningDNAGene FusionGenomicsHumansDNABioinformaticsComputer sciencesGenomicsHealth SciencesMolecular Biology

Identifiers

PMID35252882
PMCPMC8892011

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.