ArticleNature reviews. Methods primers2021
Adaptive optics for high-resolution imaging.
Article in Nature reviews. Methods primers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers.
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Who cites it
103 citing papers in PubMed, 259 citations in OpenAlex.
- Aberration correction and complementary beam subtraction in light-sheet fluorescence microscopy.Journal of biomedical optics · 2026Article
- Depth-adapted adaptive optics for three-photon microscopy.Biomedical optics express · 2026Article
- Graph-based modeling of optical system enables adaptive optics on dynamic samples with self-calibration.iScience · 2026Article
- Association Between PS-OCT Derived Polarimetric Entropy and RPE Cellular Metrics Measured With Adaptive Optics Imaging in Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2026Article
- Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics.eLife · 2026Article
- Physics-informed multi-encoder adaptive optics enables rapid aberration correction for intravital microscopy of deep complex tissue.Nature communications · 2026Article
- Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Hybrid-2D Excitonic Metasurfaces for Complex Amplitude Modulation.Nano letters · 2026Article
- Polarization-engineered aberration-resilient light sheet microscopy.bioRxiv : the preprint server for biology · 2026Article
- An end-to-end hybrid deep-learning approach for single-shot wavefront sensing and correction.Nature communications · 2026Article
- Adaptive optical correction for in vivo two-photon fluorescence microscopy with neural fields.Nature methods · 2026Article
- 3D Single-Virus Tracking: Advances in Methodology and Labeling Strategies Towards Probing the Virus-Epithelium Interaction.Viruses · 2026Review
- Single-shot, reference-less computational wavefront sensing for complex optical fields.Light, science & applications · 2026Article
- Phase-based computational adaptive optics enables artifact-free super-resolution microscopy.Communications engineering · 2026Article
- Intravital mesoscale optical imaging: challenges, techniques, and future perspectives.Biophysics reports · 2026Article
- Morphologic assessment of photoreceptors after idiopathic epiretinal membrane surgery with adaptive-optics SLO.BMC ophthalmology · 2026Article
- Rapid wavefront shaping using an optical gradient acquisition.Nature communications · 2026Article
- Tunable Bessel beam two-photon fluorescence microscopy for high-speed volumetric imaging of brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Investigating neurovascular responses of the peripapillary retinal artery to focal flicker stimulation of temporal retinal neurons in the living human eye using AO-OCT.Biomedical optics express · 2026Article
- Adaptive optics stimulated Raman scattering microscopy for topical product pharmacokinetic imaging.Biomedical optics express · 2026Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Adaptive optics (AO) is a technique that corrects for optical aberrations. It was originally proposed to correct for the blurring effect of atmospheric turbulence on images in ground-based telescopes and was instrumental in the work that resulted in the Nobel prize-winning discovery of a supermassive compact object at the centre of our galaxy. When AO is used to correct for the eye's imperfect optics, retinal changes at the cellular level can be detected, allowing us to study the operation of the visual system and to assess ocular health in the microscopic domain. By correcting for sample-induced blur in microscopy, AO has pushed the boundaries of imaging in thick tissue specimens, such as when observing neuronal processes in the brain. In this primer, we focus on the application of AO for high-resolution imaging in astronomy, vision science and microscopy. We begin with an overview of the general principles of AO and its main components, which include methods to measure the aberrations, devices for aberration correction, and how these components are linked in operation. We present results and applications from each field along with reproducibility considerations and limitations. Finally, we discuss future directions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.