Evidence map›Paper›PMID 35252716›Full record

ArticleACS omega2022

Hybrid Synthetic and Computational Study of an Optimized, Solvent-Free Approach to Curcuminoids.

Valeria A Stepanova, Andres Guerrero, Cullen Schull, Joshua Christensen, Claire Trudeau, Joshua Cook, Kyle Wolmutt, Jordan Blochwitz, Abdelrahman Ismail, Joseph K West and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Valeria A StepanovaDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.ORCID https://orcid.org/0000-0001-6026-513X
Andres GuerreroDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Cullen SchullDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Joshua ChristensenDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Claire TrudeauDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Joshua CookDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Kyle WolmuttDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Jordan BlochwitzDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Abdelrahman IsmailDepartment of Chemistry and Biochemistry, University of Wisconsin La Crosse, 1725 State Street, La Crosse, Wisconsin 54601, United States.
Joseph K WestDepartment of Chemistry, Winona State University, 175 West Mark Street, Winona, Minnesota 55987, United States.ORCID https://orcid.org/0000-0003-0021-9638
Amelia M WheatonDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Ilia A GuzeiDepartment of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID https://orcid.org/0000-0003-1976-7386
Bin YaoDepartment of Chemistry, University of North Dakota, 151 Cornell Street, Grand Forks, North Dakota 58202, United States.
Alena KubatovaDepartment of Chemistry, University of North Dakota, 151 Cornell Street, Grand Forks, North Dakota 58202, United States.ORCID https://orcid.org/0000-0002-2318-5883

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A green and optimized protocol has been developed for the preparation of symmetric 1,7-bis(aryl)-1,6-heptadiene-3,5-diones and asymmetric 2-aryl-6-arylidenecyclohexanones with modified substrate scope and good functional group tolerance. Syntheses proceed smoothly under solvent-free conditions, providing moderate to excellent product yields with a minimal workup procedure. Control experiments, spectroscopic, and computational studies support a mechanism involving the boron-assisted in situ generation of imine intermediates. Crystal structures of three curcuminoids and isolated mechanistic intermediates are reported. The data provide insight for the further development of solvent-free protocols toward diverse curcumin derivatives in the fields of pharmaceutical and synthetic chemistries.

Identifiers

PMID35252716
PMCPMC8892666

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.