Evidence map›Paper›PMID 35252694›Full record

ArticleACS omega2022

Stable Fatty Acid Solvates of Dasatinib, a Tyrosine Kinase Inhibitor: Prediction, Process, and Physicochemical Properties.

Venkata Narasayya Saladi, Bal Raju Kammari, Arthanareeswari Maruthapillai, Sudarshan Mahapatra, Ramanaiah Chennuru, Eswaraiah Sajja, Srinivasan Thirumalai Rajan, Vijayavitthal T Mathad

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Venkata Narasayya SaladiDepartment of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, India.
Bal Raju KammariPolymorph Screening and Development Laboratory, R&D center, MSN Laboratories (P) Ltd., Hyderabad 502307, Telangana, India.ORCID https://orcid.org/0000-0002-8144-0862
Arthanareeswari MaruthapillaiDepartment of Chemistry, SRM Institute of Science and Technology, Kattankulathur, Chennai 603203, India.ORCID https://orcid.org/0000-0002-1794-3967
Sudarshan MahapatraSolid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore 560012, India.
Ramanaiah ChennuruDepartment of Chemistry, Gitam Institute of Science and Technologies, Visakhapatnam 530045, Andhra Pradesh, India.
Eswaraiah SajjaPolymorph Screening and Development Laboratory, R&D center, MSN Laboratories (P) Ltd., Hyderabad 502307, Telangana, India.
Srinivasan Thirumalai RajanPolymorph Screening and Development Laboratory, R&D center, MSN Laboratories (P) Ltd., Hyderabad 502307, Telangana, India.
Vijayavitthal T MathadPolymorph Screening and Development Laboratory, R&D center, MSN Laboratories (P) Ltd., Hyderabad 502307, Telangana, India.ORCID https://orcid.org/0000-0003-4507-5367
MSN Laboratories (India) · INSRM Institute of Science and Technology · INGITAM University · INIndian Institute of Science Bangalore · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exploration of alternate solid forms for dasatinib, a potent oncogene tyrosine kinase inhibitor classified under Biopharmaceutics Classification System (BCS) class II drugs with low water solubility and high permeability, has been performed using COSMO-RS excess enthalpy (Hex) to increase dissolution. The theoretical prediction resulted in the potential for the formation of C

Identifiers

PMID35252694
PMCPMC8892647
OpenAlexW4220769240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.