Evidence map›Paper›PMID 35252630›Full record

ArticleAdvances in ophthalmology and optometry2021

Ocular blood flow as it relates to race and disease on glaucoma.

Brent Siesky, Alon Harris, Alice C Verticchio Vercellin, Giovanna Guidoboni, James C Tsai

Open access · greenAbstract read
In one paragraph

Article in Advances in ophthalmology and optometry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Effect of treatment with carteolol and latanoprost in newly diagnosed primary open-angle glaucoma on peripapillary vessel density.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Brent SieskyIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Alon HarrisIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Alice C Verticchio VercellinIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Giovanna GuidoboniDepartment of Electrical Engineering and Computer Science, Department of Mathematics, University of Missouri, Columbia, MO, United States.
James C TsaiIcahn School of Medicine at Mount Sinai, New York, NY, United States.
Icahn School of Medicine at Mount Sinai · USIstituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Missouri · US

Funding

Integration of clinical measures and theoretical modeling to quantify sectorial specific changes in ocular structure, function, and hemodynamicsR01EY030851 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARCIERO, JULIA, HARRIS, ALON · 2020 to 2023
$1.3M
NEI NIH HHS R01 EY030851
6 · The paper itself

Abstract

Glaucoma is a multifactorial progressive and degenerative optic neuropathy representing one of the world's leading cause of irreversible blindness. Currently, reduction of intraocular pressure remains the only universally approved therapy, yet a wealth of studies has identified significant vascular contributions to the disease process in certain individuals. Population-based studies have identified important racial disparities and differential risk factors in glaucoma prevalence, incidence, and progression. A more significant vascular component has been identified in persons of African descent. Elucidating risk modifiers, including genetic and racial influence, is important when considering individually tailored clinical management of glaucoma. The application of artificial intelligence and mathematical modeling inclusive of demographic considerations, vascular health, and clinical biomarkers may help reduce disease disparities, advance personalized medicine, and provide a comprehensive model of glaucoma.

Indexed as

African descentartificial intelligencedemographicsdisparityGlaucomamodelingocular blood flowrace

Identifiers

PMID35252630
PMCPMC8896810
OpenAlexW3182086396

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.