ArticleClinical and translational radiation oncology2022
Scalp angiosarcoma treated with linear accelerator-based boron neutron capture therapy: A report of two patients.
Article in Clinical and translational radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07058116 (Accelerator-based Boron Neutron Capture Therapy), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerator-based Boron Neutron Capture Therapy (BNCT) in the Treatment of Locally Recurrent Head and Neck Carcinoma: A Phase I Study.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Development of Linear Interpolation System for SMK Model Parameters Evaluated from Cellular-Scale Simulation (LISMEC) and its application to BNCT dosimetry.Journal of radiation research · 2026Article
- The boron uptake via LAT1 and survival analysis after boron neutron capture therapy in canine hemangiosarcoma cell lines.Frontiers in veterinary science · 2026Article
- Targeted Nanoboron Delivery Platform for Boron Neutron Capture Therapy in Refractory Solid Tumors.International journal of nanomedicine · 2026Review
- Advances in Clinical Trials of Boron Neutron Capture Therapy.Research (Washington, D.C.) · 2026Review
- Cobaltabis(Dicarbollide) [Pharmaceuticals (Basel, Switzerland) · 2024Article
- A national survey of medical staffs' required capability and workload for accelerator-based boron neutron capture therapy.Journal of radiation research · 2024Article
- A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target.Scientific reports · 2024Article
- The Effects of Boron Neutron Capture Therapy on the Lungs in Recurrent Breast Cancer Treatment.Cureus · 2024Article
- Correlation between L-amino acid transporter 1 expression and 4-borono-2-Cancer medicine · 2023Article
- Dose Rate Effect on Cell Survival in BNCT.Current issues in molecular biology · 2023Article
- Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target.Journal of radiation research · 2023Article
- Development of optimization method for uniform dose distribution on superficial tumor in an accelerator-based boron neutron capture therapy system.Journal of radiation research · 2023Article
- Initiatives Toward Clinical Boron Neutron Capture Therapy in Japan.Cancer biotherapy & radiopharmaceuticals · 2023Article
- Clinical significance of local control of primary tumour in definitive radiotherapy for scalp angiosarcomas.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Acral cutaneous malignant melanoma treated with linear accelerator-based boron neutron capture therapy system: a case report of first patient.Frontiers in oncology · 2023Article
- Analyzing spatial distribution betweenEJNMMI physics · 2022Article
- Intensity-modulated irradiation for superficial tumors by overlapping irradiation fields using intensity modulators in accelerator-based BNCT.Journal of radiation research · 2022Article
- First Experiences of Pilot Clinical Studies on Boron Neutron Capture Therapy for Recurrent Gastrointestinal Cancers Using an Intravenous Injection ofIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
21 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study reports the first-in-human use of a linear accelerator-based boron neutron capture therapy (BNCT) system and the first treatment of patients with scalp-angiosarcoma with accelerator-based BNCT. PATIENTS AND
methodsA single-center open-label phase I clinical trial has been conducted using the system since November 2019. Patients with a localized node-negative scalp-angiosarcoma along with the largest diameter of the tumor ≤ 15 cm who refused primary surgery and chemotherapy were enrolled. After administration of boronophenylalanine (BPA), a single treatment of BNCT with the maximum dose delivered to the skin being 12 Gy-Eq was performed. The safety and effectiveness of accelerator-based BNCT therapy for localized scalp angiosarcoma were evaluated.
resultsScalp-angiosarcoma of the two patients did not develop the dose-limiting toxicity in the clinical trial. They reached CR within half a year and did not exhibit in-field failure 20 months after BNCT without any severe treatment-related adverse events. Although a grade 3 adverse event of an asymptomatic but increased serum amylase level was noted in both patients, it relieved without any treatment. Additionally, no severe acute dermatitis was observed for both patients, which is typically seen with conventional primary radiotherapy.
conclusionsIt was suggested that BNCT would be a promising treatment modality for scalp-angiosarcoma, which is difficult to treat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.