Evidence map›Paper›PMID 35252593›Full record

ReviewHealth science reports2022

Mucormycosis infection in patients with COVID-19: A systematic review.

SeyedAhmad SeyedAlinaghi, Amirali Karimi, Alireza Barzegary, Zahra Pashaei, Amir Masoud Afsahi, Sanam Alilou, Nazanin Janfaza, Alireza Shojaei, Fatemeh Afroughi, Parsa Mohammadi and 7 more

RetractedAbstract readReviewRetracted Publication
In one paragraph

Review in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Hearing loss and COVID-19: an umbrella review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
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  5. The prognostic significance of insulin resistance in COVID-19: a review.Journal of diabetes and metabolic disorders · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

SeyedAhmad SeyedAlinaghiIranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0003-3210-7905
Amirali KarimiSchool of Medicine Tehran University of Medical Sciences Tehran Iran.
Alireza BarzegarySchool of Medicine Islamic Azad University Tehran Iran.ORCID https://orcid.org/0000-0002-0512-7014
Zahra PashaeiIranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences Tehran Iran.
Amir Masoud AfsahiDepartment of Radiology School of Medicine, University of California, San Diego (UCSD) San Diego California USA.
Sanam AlilouSchool of Medicine Tehran University of Medical Sciences Tehran Iran.
Nazanin JanfazaInternal Medicine Department Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences Tehran Iran.
Alireza ShojaeiIranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences Tehran Iran.
Fatemeh AfroughiSchool of Medicine Islamic Azad University Tehran Iran.
Parsa MohammadiSchool of Medicine Tehran University of Medical Sciences Tehran Iran.
Yasna SoleimaniSchool of Medicine Islamic Azad University Tehran Iran.
Newsha NazarianSchool of Medicine Islamic Azad University Tehran Iran.
Ava AmiriIranian Research Center for HIV/AIDS Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences Tehran Iran.
Marcarious M TantuoyirSchool of Medicine Tehran University of Medical Sciences Tehran Iran.
Shahram OliaeiHBOT Research Center Golestan Hospital, Islamic Republic of Iran, Navy and AJA Medical University Tehran Iran.
Esmaeil MehraeenDepartment of Health Information Technology Ardebil University of Medical Sciences Ardebil Iran.ORCID https://orcid.org/0000-0003-4108-2973
Omid DadrasDepartment of Global Health and Socioepidemiology Graduate School of Medicine, Kyoto University Kyoto Japan.ORCID https://orcid.org/0000-0001-9385-2170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral reports previously described mucormycosis co-infection in patients with COVID-19. As mucormycosis and COVID-19 co-infection might adversely affect patients' outcomes, we aimed to systematically review the related evidence and the subsequent outcomes.

methodsWe conducted a systematic review of relevant articles searching the keywords in the online databases of PubMed, Scopus, Embase, Cochrane, and Web of Science. All the records from the start of the pandemic until June 12th, 2021 underwent title/abstract and then full-text screening process, and the eligible studies were included. We did not include any language or time restrictions for the included studies.

resultsWe found 31 eligible studies reporting 144 total cases of COVID-19 and mucormycosis co-infection. The nose, cranial sinuses, and orbital cavity were the most commonly involved organs, although the cerebrum, lungs, and heart were also involved in the studies. Pre-existing diabetes mellitus (DM), as well as corticosteroid use, were the most commonly identified risk factors, but other underlying conditions and immunomodulatory drug use were also present in several cases. Aspergillus was the most commonly reported micro-organism that caused further co-infections in patients with concurrent COVID-19 and mucormycosis. As most of the studies were case reports, no reliable estimate of the mortality rate could be made, but overall, 33.6% of the studied cases died.

conclusionEarly diagnosis of mucormycosis co-infection in COVID-19 patients and selecting the right treatment plan could be a challenge for physicians. Patients with underlying co-morbidities, immunocompromised patients, and those receiving corticosteroids are at higher risk of developing mucormycosis co-infection and it is crucial to have an eye examination for early signs and symptoms suggesting a fungal infection in these patients.

Indexed as

black fungusCOVID‐19mucormycosisSARS‐CoV‐2

Identifiers

PMID35252593
PMCPMC8885749

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.