Evidence map›Paper›PMID 35252446›Full record

ArticleBioMed research international2022

A Joint Model for Unbalanced Nested Repeated Measures with Informative Drop-Out Applied to Ambulatory Blood Pressure Monitoring Data.

Enas M Ghulam, Jane C Khoury, Roman Jandarov, Raouf S Amin, Eleni-Rosalina Andrinopoulou, Rhonda D Szczesniak

RetractedAbstract readRetracted Publication
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Enas M GhulamBasic Science Department, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.ORCID https://orcid.org/0000-0002-7867-8618
Jane C KhouryDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Roman JandarovDepartment of Environmental Health, University of Cincinnati, Cincinnati, USA.
Raouf S AminDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.
Eleni-Rosalina AndrinopoulouDepartment of Biostatistics, Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands.
Rhonda D SzczesniakDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, USA.ORCID https://orcid.org/0000-0003-0705-715X

Funding

Vascular Functions in Children with Sleep Disordered BreathingR01HL080670 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI AMIN, RAOUF S. · 2006 to 2010
$2.8M
R01- Mapping environmental contributions to rapid lung disease progression in cystic fibrosisR01HL141286 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SZCZESNIAK, RHONDA · 2019 to 2023
$2.3M
Mechanisms Mediating C/V Disease in Children with OSAR01HL070907 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI AMIN, RAOUF S · 2003 to 2007
$1.8M
Preventing rapid decline in CF: statistical research career commitmentK25HL125954 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SZCZESNIAK, RHONDA · 2015 to 2019
$762k
NHLBI NIH HHS K25 HL125954NHLBI NIH HHS R01 HL070907NHLBI NIH HHS R01 HL080670NHLBI NIH HHS R01 HL141286
6 · The paper itself

Abstract

This study proposes a Bayesian joint model with extended random effects structure that incorporates nested repeated measures and provides simultaneous inference on treatment effects over time and drop-out patterns. The proposed model includes flexible splines to characterize the circadian variation inherent in blood pressure sequences, and we assess the effectiveness of an intervention to resolve pediatric obstructive sleep apnea. We demonstrate that the proposed model and its conventional two-stage counterpart provide similar estimates of nighttime blood pressure but estimates on the mean evolution of daytime blood pressure are discrepant. Our simulation studies tailored to the motivating data suggest reasonable estimation and coverage probabilities for both fixed and random effects. Computational challenges of model implementation are discussed.

Indexed as

HypertensionSleep Apnea, ObstructiveBayes TheoremBlood PressureBlood Pressure Monitoring, AmbulatoryChildCircadian RhythmHumans

Identifiers

PMID35252446
PMCPMC8896933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.