Evidence map›Paper›PMID 35252404›Full record

ArticleFrontiers in cardiovascular medicine2022

Pressure-Natriuresis Response Is Diminished in Old Age.

Yang Gyun Kim, Ju-Young Moon, Bermseok Oh, Ho Jun Chin, Dong Ki Kim, Jung Hwan Park, Sung Joon Shin, Bum Soon Choi, Chun Soo Lim, Sang Ho Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Yang Gyun KimDivision of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Ju-Young MoonDivision of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Bermseok OhDepartment of Biomedical Engineering, School of Medicine, Kyung Hee University, Seoul, South Korea.
Ho Jun ChinDivision of Nephrology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Dong Ki KimDivision of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Jung Hwan ParkDivision of Nephrology, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea.
Sung Joon ShinDivision of Nephrology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea.
Bum Soon ChoiDivision of Nephrology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Chun Soo LimDivision of Nephrology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, South Korea.
Sang Ho LeeDivision of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.
Kyung Hee University · KRCatholic University of Korea · KRDongguk University Ilsan Hospital · KRKonkuk University · KRSeoul National University Bundang Hospital · KRSeoul National University Hospital · KRSNUH SMG-SNU Boramae Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAge-related alterations in renal sodium handling affect blood pressure (BP). We aimed to clarify whether the pressure-natriuresis response changes with age, leading to BP elevation.

methodsA total of 4,859 participants with normal renal function from the Korean Genome and Epidemiology Study (KoGES) and 235 patients with non-diabetic chronic kidney disease (CKD) from the ESPECIAL trial were included and divided into the younger and older groups. In ESPECIAL, participants took olmesartan from weeks 0 to 16 and were educated about a low-salt diet (LSD) from weeks 8 to 16.

resultsIn both studies, older participants showed lower estimated glomerular filtration rate (eGFR) and urine concentration index and higher albuminuria. In KoGES, BP was higher and urine sodium was lower in older participants. In ESPECIAL, diastolic BP at 0 week was lower in older participants. Olmesartan reduced BP in both groups, whereas LSD decreased systolic BP only in older participants. Urine sodium increased in younger participants but decreased in older participants after olmesartan use. In KoGES, urine sodium was correlated with BP in both groups after adjusting for age, sex, and eGFR; however, the correlation coefficient was lower in older participants. In ESPECIAL, only younger participants showed a significant positive association between systolic BP and urine sodium in multiple regression analysis.

conclusionsThe pressure-natriuresis response was diminished in older participants with or without CKD.

Indexed as

hypertensionnatriuresisoldpressuresalt sensitivity

Identifiers

PMID35252404
PMCPMC8889037
OpenAlexW4213356163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.