Evidence map›Paper›PMID 35252396›Full record

SynthesisFrontiers in cardiovascular medicine2022

Trimethylamine N-Oxide in Heart Failure: A Meta-Analysis of Prognostic Value.

Xingxing Li, Zongjing Fan, Jie Cui, Dong Li, Jinjin Lu, Xiaoyun Cui, Liandi Xie, Yang Wu, Qian Lin, Yan Li

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trimethylamine-N-oxide: the microbial cue in immune-mediated disorders.Trends in endocrinology and metabolism: TEM · 2026
    Review
  4. Article
  5. Review
  6. The Gut-Heart Axis: A Microbiome-Centered Perspective on Heart Failure.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Gut-heart axis: cardiac remodeling and heart failure in the context of inflammatory bowel disease and dysbiosis.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xingxing LiSecond Clinical School of Medicine, Beijing University of Chinese Medicine, Beijing, China.
Zongjing FanDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Jie CuiDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Dong LiDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Jinjin LuDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Xiaoyun CuiDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Liandi XieDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yang WuDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Qian LinDepartment of Cardiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Yan LiDepartment of Cardiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Beijing University of Chinese Medicine · CNDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe present study aimed to explore the prognostic value of trimethylamine N-oxide (TMAO) in heart failure (HF).

methodsPubMed, Excerpta Medica Database (EMBASE), Cochrane Library, Web of Science, Wanfang Database, SINOMED, China Science and Technology Journal Database (VIP), and China National Knowledge Infrastructure (CNKI) were searched up to June 1, 2021. Studies recording the major adverse cardiovascular events (MACEs) or all-cause mortality in HF patients and their circulating TMAO concentrations were included. Meta-analysis was performed using Stata 13.0.

resultsTen articles (12 studies) involving 13,425 participants from 2014 to 2021 were considered. Compared to low-level TMAO, elevated TMAO was correlated with MACEs and all-cause mortality in HF (RR: 1.28, 95% CI: 1.17, 1.39,

conclusionElevated TMAO may be an adverse prognostic indicator in patients with HF. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=267208.

Indexed as

all-cause mortalityheart failuremajor adverse cardiovascular eventsmeta-analysistrimethylamine N-oxide

Identifiers

PMID35252396
PMCPMC8888860
OpenAlexW4213263592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.