SynthesisFrontiers in cardiovascular medicine2022
Prognostic Value of Global Longitudinal Strain in Asymptomatic Aortic Stenosis: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Prognostic value of global longitudinal strain in hypertrophic cardiomyopathy: A systematic review and meta-analysis.Clinical cardiology · 2022Pooled it
- Prognostic value of ventricular longitudinal strain in patients undergoing transcatheter aortic valve replacement: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- External Validation of Two Different Cardiac Damage Staging Systems for Aortic Stenosis in Patients Treated with Surgical Aortic Valve Replacement.Journal of clinical medicine · 2026Article
- Reclassifying Aortic Stenosis Severity: Combined Energy Loss Index and Global Longitudinal Strain Assessment Identifies Subgroups with Differential Myocardial Function and May Improve Risk Stratification in Aortic Stenosis.Medical sciences (Basel, Switzerland) · 2026Article
- Stress Echocardiography in Aortic Stenosis: From Diagnostic Challenges to Guideline-Endorsed Clinical Applications.Journal of clinical medicine · 2025Article
- Calcific Aortic Valve Stenosis: A Focal Disease in Older and Complex Patients-What Could Be the Best Time for an Appropriate Interventional Treatment?Journal of clinical medicine · 2025Review
- Prevalence, Mechanisms, and Prognostic Impact of Effort Intolerance in Patients With Asymptomatic/Minimally Symptomatic Aortic Stenosis.Journal of the American Heart Association · 2025Article
- Aortic Stenosis Prevention: Is a New Cardiovascular Disease Paradigm Coming of Age?Journal of clinical medicine · 2025Review
- A "Watchful Surgery" Approach: Timing and Valve Choice for Mildly Symptomatic Mitral and Aortic Valve Disease.Journal of surgery and research · 2025Article
- Left Ventricular Hypertrophy in Aortic Stenosis: Early Cell and Matrix Regression 2 Months Post-Aortic Valve Replacement.Circulation. Cardiovascular imaging · 2024Observational
- Left Ventricular Diastolic Dysfunction Predicts Global Longitudinal Strain Recovery after Surgical Aortic Valve Replacement.Diagnostics (Basel, Switzerland) · 2024Article
- Sex Differences in Aortic Stenosis: From the Pathophysiology to the Intervention, Current Challenges, and Future Perspectives.Journal of clinical medicine · 2024Review
- The Relative Apical Sparing Strain Pattern in Severe Aortic Valve Stenosis: A Marker of Adverse Cardiac Remodeling.Journal of personalized medicine · 2024Article
- Prognostic Value of Cardiac Magnetic Resonance Feature Tracking Strain in Aortic Stenosis.Journal of cardiovascular development and disease · 2024Article
- Current and novel echocardiographic assessment of left ventricular systolic function in aortic stenosis-A comprehensive review.Echocardiography (Mount Kisco, N.Y.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsThe presence of impaired global longitudinal strain (GLS) may be a valuable bio-marker in the early diagnosis for left ventricle (LV) impairment, which would help scrutinize asymptomatic aortic stenosis (AS) patients with high risk of adverse outcomes, such as major adverse cardiovascular events (MACE).
methodsThe study was prospectively registered in PROPSERO (CRD 42021223472). Databases, such as Pubmed, Embase, Cochrane Library, Web of science, and Scopus were searched for studies evaluating the impact of impaired GLS on MACE, all-cause mortality, and aortic valve replacement (AVR) in asymptomatic AS. Hazard ratios (
resultsEventually, a total of nine studies reporting 1,512 patients were enrolled. Compared with the normal GLS group, impaired GLS significantly increased MACE (
conclusionsThe presence of impaired GLS substantially worsens the outcomes for adverse cardiovascular events in asymptomatic patients with AS regardless of LVEF or AS severity or follow-up time or mean aortic valve pressure gradient, which highlights the importance of incorporating impaired GLS into risk algorithms in asymptomatic AS. SYSTEMATIC REVIEW REGISTRATION: PROSPERO (registration number: CRD42021223472).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.