Evidence map›Paper›PMID 35252351›Full record

ArticleFrontiers in molecular biosciences2022

iCn3D: From Web-Based 3D Viewer to Structural Analysis Tool in Batch Mode.

Jiyao Wang, Philippe Youkharibache, Aron Marchler-Bauer, Christopher Lanczycki, Dachuan Zhang, Shennan Lu, Thomas Madej, Gabriele H Marchler, Tiejun Cheng, Li Chuin Chong and 13 more

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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  17. ISME communications · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jiyao WangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Philippe YoukharibacheNational Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Aron Marchler-BauerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Christopher LanczyckiNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Dachuan ZhangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Shennan LuNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Thomas MadejNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Gabriele H MarchlerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Tiejun ChengNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Li Chuin ChongBeykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Beykoz, Turkey.
Sarah ZhaoCary Academy, Cary, NC, United States.
Kevin YangUniversity of Maryland, College Park, MD, United States.
Jack LinUniversity of Washington, Tacoma, WA, United States.
Zhiyu ChengUniversity of California, Irvine, Irvine, CA, United States.
Rachel DunnUniversity of British Columbia, Vancouver, BC, Canada.
Sridhar Acharya MalkaramWest Virginia State University, Institute, WV, United States.
Chin-Hsien TaiNational Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
David EnomaNoma Technology, Port Harcourt, Nigeria.
Ben BusbyDNAnexus, Pittsburgh, PA, United States.
Nicholas L JohnsonNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Francesco TabaroEuropean Molecular Biology Laboratory, EMBL Rome, Monterotondo, Italy.
Guangfeng SongNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, United States.
Yuchen GeJohns Hopkins University, Baltimore, MD, United States.

Funding

National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7M
Structural data science methods and software to study immunotherapeutic proteinsZIHBC012005 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOUKHARIBACHE, PHILIPPE · 2020 to 2024
$753k
Structural basis of viral RBDs binding to cell receptorsZIABC011990 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI YOUKHARIBACHE, PHILIPPE · 2020 to 2024
$188k
6 · The paper itself

Abstract

iCn3D was initially developed as a web-based 3D molecular viewer. It then evolved from visualization into a full-featured interactive structural analysis software. It became a collaborative research instrument through the sharing of permanent, shortened URLs that encapsulate not only annotated visual molecular scenes, but also all underlying data and analysis scripts in a FAIR manner. More recently, with the growth of structural databases, the need to analyze large structural datasets systematically led us to use

Indexed as

3d viewerbatch modedelphiiCn3DNode.js scriptPython scriptstructural analysisweb-based

Identifiers

PMID35252351
PMCPMC8892267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.