Evidence map›Paper›PMID 35252350›Full record

ReviewFrontiers in molecular biosciences2022

Intracellular pH Control by Membrane Transport in Mammalian Cells. Insights Into the Selective Advantages of Functional Redundancy.

Denis Doyen, Mallorie Poët, Gisèle Jarretou, Didier F Pisani, Michel Tauc, Marc Cougnon, Mederic Argentina, Yann Bouret, Laurent Counillon

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. Cavity acidification limits ferritin iron biomineralization.Journal of inorganic biochemistry · 2026
    Article
  4. Cancer: A bioelectric disease?Clinical and translational medicine · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Development of a Chemogenetic Approach to Manipulate Intracellular pH.Journal of the American Chemical Society · 2023
    Article
  18. Article
  19. How Does Our Knowledge on the NaFrontiers in physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Denis DoyenUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Mallorie PoëtUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Gisèle JarretouUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Didier F PisaniUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Michel TaucUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Marc CougnonUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Mederic ArgentinaUniversité Côte d'Azur, CNRS, Institut de Physique de Nice, INPHYNI, Nice, France.
Yann BouretCentre Hospitalier Universitaire de Nice, Service de Médecine Intensive Réanimation, Hôpital Archet 1, Nice, France.
Laurent CounillonUniversité Côte d'Azur, CNRS, Laboratoire de Physiomédecine Moléculaire, Nice, France.
Université Côte d'Azur · FRLaboratoire de PhysioMédecine Moléculaire · FRCentre Hospitalier Universitaire de Nice · FRCentre National de la Recherche Scientifique · FRLaboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracellular pH is a vital parameter that is maintained close to neutrality in all mammalian cells and tissues and acidic in most intracellular compartments. After presenting the main techniques used for intracellular an vesicular pH measurements we will briefly recall the main molecular mechanisms that affect and regulate intracellular pH. Following this we will discuss the large functional redundancy found in the transporters of H

Indexed as

functional redundancymathematical modellingnatural selectionpH measurementspH regulationtransmembrane transport

Identifiers

PMID35252350
PMCPMC8896879
OpenAlexW4213178103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.