ArticleFrontiers in medicine2022
Sleep Quality Is Associated With Severe Meibomian Gland Disruption in Dry Eye.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association between dry eye disease and poor sleep quality in the elderly.BMC ophthalmology · 2026Article
- Beyond the Eye: Sleep Fragmentation, Autonomic Dysregulation, and Mitochondrial Dysfunction as a Common Biological Soil for Meibomian Gland Pathology.Investigative ophthalmology & visual science · 2026Article
- Impact of smoking exposure on meibomian gland morphology and tear film stability: a cross-sectional study.Frontiers in medicine · 2025Article
- The ILuxInternational journal of ophthalmology · 2024Article
- Association of Dry Eye Diseases and Auditory Sensitivity.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the association between sleep quality and meibomian gland dropout characteristics in dry eye patients.
methodsThis cross-sectional study involved 172 dry eye patients with no history of conditions or factors that could confound dry eye disease (DED) and/or meibomian gland dropout. Participants underwent a comprehensive anterior eye assessment. The validated Athens Insomnia Scale (AIS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess sleep quality. The measured outcomes were dry eye symptoms via the Ocular Surface Disease Index (OSDI), tear breakup time (TBUT), corneal fluorescein staining, meibomian gland function, and extent of meibomian gland dropout.
resultsOf the dry eye participants, 34.9% had severe meibomian gland dropout (SMD) and 41.3% of the subjects had poor sleep quality. Patients with poor sleep quality had greater Meibomian gland dropout while the sleep AIS and PSQI scores were significantly correlated with Meibomian gland dropout (
conclusionIt was found that greater meibomian gland dropout in poor sleep quality individuals is especially related to use of sleep medication, poor habitual sleep efficiency, and sleep disturbance. This finding suggests a need for long-term studies of anterior eye health in people with poor sleep quality.
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