ArticleFrontiers in cellular and infection microbiology2022
CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages.
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Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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0cells of the map it votes in
20citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Low Shear Stress Promotes Atherosclerosis by Mediating Pathological Accumulation of Endothelial Lipid Droplets via the KLF4/TFEB/ATP1A1 Axis.Journal of cardiovascular development and disease · 2026Article
- Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Implant-derived titanium particles impair macrophage bacterial clearance via TRPC1 and lysosomal dysfunction.PNAS nexus · 2026Article
- CFTR modulator therapy drives microbiome restructuring through improved host physiology in cystic fibrosis: the IMMProveCF phase IV trial.Nature communications · 2025Article
- Physiologically informed in vitro framework reveals context-dependent combinatory activity of niclosamide-colistin against Gram-negative bacteria.The Journal of antimicrobial chemotherapy · 2025Article
- Review
- Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches.Bioelectricity · 2025Review
- Defective Cystic Fibrosis Transmembrane Conductance Regulator Accelerates Skeletal Muscle Aging by Impairing Autophagy/Myogenesis.Journal of cachexia, sarcopenia and muscle · 2025Article
- Autophagy in the lung: guardian of homeostasis or driver of disease.Autophagy reports · 2025Review
- Wound repair and immune function in theFrontiers in cellular and infection microbiology · 2025Review
- Effect of CFTR Modulators on Oxidative Stress and Autophagy in Non-CFTR-Expressing Cells.International journal of molecular sciences · 2024Article
- A New Frontier in Cystic Fibrosis Pathophysiology: How and When Clock Genes Can Affect the Inflammatory/Immune Response in a Genetic Disease Model.Current issues in molecular biology · 2024Review
- Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease.Brain, behavior, and immunity · 2024Article
- COPII cage assembly factor Sec13 integrates information flow regulating endomembrane function in response to human variation.Scientific reports · 2024Article
- Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis.Nature cancer · 2024Article
- TRAF6 triggers Mycobacterium-infected host autophagy through Rab7 ubiquitination.Cell death discovery · 2023Article
- Review
- Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor.The European respiratory journal · 2023Article
- Impact ofInternational journal of molecular sciences · 2022Review
- Emerging Concepts in Defective Macrophage Phagocytosis in Cystic Fibrosis.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 4 countries.
Asmaa BadrDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Mostafa EltobgyDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Kathrin KrauseDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Kaitlin HamiltonDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Shady EstfanousDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Kylene P DailyDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Arwa Abu KhweekDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Ahmad HegaziDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Midhun N K AnneDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Cierra CaraficeDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Frank Robledo-AvilaCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United States.
Youssra SaqrDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Xiaoli ZhangCenter for Biostatistics, Ohio State University, Columbus, OH, United States.
Tracey L BonfieldDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Mikhail A GavrilinDepartment of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Columbus, OH, United States.
Santiago Partida-SanchezCenter for Microbial Pathogenesis, Nationwide Children's Hospital, Columbus, OH, United States.
Stephanie SeveauDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
Estelle Cormet-BoyakaDepartment of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, United States.
Amal O AmerDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.
The Ohio State University · USCase Western Reserve University · USNationwide Children's Hospital · USMansoura University · EGMax Planck Unit for the Science of Pathogens · DE
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3MThe OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9MUnraveling the role of the CFTR ion channel in susceptibility to SARS-CoV-2 infection and inflammationR01AI124121 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2016 to 2020
$3.7MTHE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITYR01AI159452 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, SEVEAU, STEPHANIE M M · 2021 to 2025
$3.7MHost Responses to the Pore-Forming Toxin Listeriolysin OR01AI157205 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, BOYAKA, PROSPER N · 2021 to 2025
$3.2MThe role of microRNA-calibrated autophagy in innate immunity and inflammationR01HL127651 · NHLBI · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2015 to 2018
$1.5MAlzheimer’s Disease Biomarker for Diagnosis and PrognosisR21AG067755 · NIA · OHIO STATE UNIVERSITY · PI AMER, AMAL O, TARAWNEH, RAWAN · 2020 to 2021
$417kNCATS NIH HHS UL1 TR002733NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL127651NIAID NIH HHS R01 AI124121NIAID NIH HHS R01 AI157205NIAID NIH HHS R01 AI159452NIA NIH HHS R21 AG067755
Abstract
Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as
Indexed as
Burkholderia cenocepaciaCystic FibrosisAnimalsCystic Fibrosis Transmembrane Conductance RegulatorHydrogen-Ion ConcentrationLysosomesMacrophagesMiceCystic Fibrosis Transmembrane Conductance Regulatorautophago-lysosomesautophagosomesautophagyBurkholderia cenocepacia clearanceCFTR modulatorscystic fibrosislysosomal acidificationmacrophages
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.