Evidence map›Paper›PMID 35252028›Full record

ReviewFrontiers in cellular and infection microbiology2022

Advances in the Rapid Diagnostic of Viral Respiratory Tract Infections.

Gratiela Gradisteanu Pircalabioru, Florina Silvia Iliescu, Grigore Mihaescu, Alina Irina Cucu, Octavian Narcis Ionescu, Melania Popescu, Monica Simion, Liliana Burlibasa, Mihaela Tica, Mariana Carmen Chifiriuc and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Rapid microbiological respiratory point-of-care testing: a qualitative study with primary care clinicians.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025
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  16. Bioscience of microbiota, food and health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Gratiela Gradisteanu PircalabioruResearch Institute of the University of Bucharest, Bucharest, Romania.
Florina Silvia IliescuNational Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
Grigore MihaescuFaculty of Biology, University of Bucharest, Bucharest, Romania.
Alina Irina CucuFaculty of Biology, University of Bucharest, Bucharest, Romania.
Octavian Narcis IonescuNational Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
Melania PopescuNational Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
Monica SimionNational Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
Liliana BurlibasaFaculty of Biology, University of Bucharest, Bucharest, Romania.
Mihaela TicaEmergency University Hospital, Bucharest, Romania.
Mariana Carmen ChifiriucResearch Institute of the University of Bucharest, Bucharest, Romania.
Ciprian IliescuNational Institute for Research and Development in Microtechnologies-IMT, Bucharest, Romania.
National Institute for Research and Development in Microtechnologies · ROUniversity of Bucharest · ROAcademy of Romanian Scientists · ROClinical Emergency Hospital Bucharest · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral infections are a significant public health problem, primarily due to their high transmission rate, various pathological manifestations, ranging from mild to severe symptoms and subclinical onset. Laboratory diagnostic tests for infectious diseases, with a short enough turnaround time, are promising tools to improve patient care, antiviral therapeutic decisions, and infection prevention. Numerous microbiological molecular and serological diagnostic testing devices have been developed and authorised as benchtop systems, and only a few as rapid miniaturised, fully automated, portable digital platforms. Their successful implementation in virology relies on their performance and impact on patient management. This review describes the current progress and perspectives in developing micro- and nanotechnology-based solutions for rapidly detecting human viral respiratory infectious diseases. It provides a nonexhaustive overview of currently commercially available and under-study diagnostic testing methods and discusses the sampling and viral genetic trends as preanalytical components influencing the results. We describe the clinical performance of tests, focusing on alternatives such as microfluidics-, biosensors-, Internet-of-Things (IoT)-based devices for rapid and accurate viral loads and immunological responses detection. The conclusions highlight the potential impact of the newly developed devices on laboratory diagnostic and clinical outcomes.

Indexed as

Biosensing TechniquesCommunicable DiseasesRespiratory Tract InfectionsHumansMicrofluidicsSerologic TestsbiosensorsIoT - internet of thingsmicrofluidicspoint-of-careviral respiratory infection

Identifiers

PMID35252028
PMCPMC8895598
OpenAlexW4211242495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.