ArticleSchizophrenia research. Cognition2022
A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders.
Article in Schizophrenia research. Cognition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Predicting schizophrenia spectrum disorders in pediatric outpatients: a prospective validation of the child psychosis-risk screening system.Frontiers in child and adolescent psychiatry · 2026Article
- Wide Range Achievement Test word reading subtest score as an indicator of premorbid intellectual disability in serious mental illness.Schizophrenia research. Cognition · 2025Article
- A Machine-Learning-Based Analysis of Resting State Electroencephalogram Signals to Identify Latent Schizotypal and Bipolar Development in Healthy University Students.Diagnostics (Basel, Switzerland) · 2025Article
- Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors.Psychological medicine · 2025Article
- Why clinical neuropsychology matters in schizophrenia care.Frontiers in psychology · 2025Review
- Association between cognitive function, antioxidants, and clinical variables in Chinese patients with schizophrenia.BMC psychiatry · 2024Article
- Is source-resolved magnetoencephalographic mismatch negativity a viable biomarker for early psychosis?The European journal of neuroscience · 2024Article
- Central insulin dysregulation in antipsychotic-naïve first-episode psychosis: In silico exploration of gene expression signatures.Psychiatry research · 2024Article
- Septotemporal Variation of Information Processing in the Hippocampus of Fmr1 KO Rat.Developmental neuroscience · 2024Article
- Effect of computerized cognitive remediation therapy on mental time travel in patients with schizophrenia- a pilot randomized controlled trial.Frontiers in psychiatry · 2024Article
- Working memory and sensory memory in subclinical high schizotypy: An avenue for understanding schizophrenia?The European journal of neuroscience · 2023Review
- Studies on the mechanism of Toxoplasma gondii Chinese 1 genotype Wh6 strain causing mice abnormal cognitive behavior.Parasites & vectors · 2023Article
- Attentional M100 gain modulation localizes to auditory sensory cortex and is deficient in first-episode psychosis.Human brain mapping · 2023Article
- Diagnostic specificity of the child psychosis-risk screening system with a focus on the differentiation of schizophrenia spectrum disorders and neurodevelopmental disorders.Frontiers in child and adolescent psychiatry · 2023Article
- How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?Disease models & mechanisms · 2022Article
- Current Evidence and Theories in Understanding the Relationship between Cognition and Depression in Childhood and Adolescence: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Baseline global brain structural and functional alterations at the time of symptom onset can predict subsequent cognitive deterioration in drug-naïve first-episode schizophrenia patients: Evidence from a follow-up study.Frontiers in psychiatry · 2022Article
- Cognitive functioning in a group of adolescents at risk for psychosis.Frontiers in psychiatry · 2022Article
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6 authors.
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Abstract
Cognitive impairments are core features of established schizophrenia spectrum disorders (SSD). However, it remains unclear whether specific cognitive functions are differentially impaired pre-onset and at what age these impairments can be detected. The purpose of this review was to elucidate these issues through a systematic summary of results from longitudinal studies investigating impairment in specific cognitive domains as antecedents of SSD. Relevant studies were identified by electronic and manual literature searches and included any original study of cognitive domains any time pre-onset of SSDs that included a control group. Effect sizes were calculated by domain for studies comparing high-risk participants who developed SSD with those who did not. The strongest evidence for impairment pre-onset was for mental processing speed, verbal learning and memory, executive function, and social cognition. Some verbal impairments, like language abilities at age 3 and verbal learning and memory at age 7, may develop as static deficits. Conversely, some non-verbal impairments, like mental processing speed, visuospatial abilities, and visual working memory manifest as developmental lag and become significant later in life. Most effect sizes were small to moderate, except for verbal fluency (d' = 0,85), implying this impairment as central in high-risk participants who develop SSD. The present review documents extensive cognitive impairments pre-onset of SSD, and that these impairments start early in life, in line with the neurodevelopmental hypothesis of schizophrenia. Increased knowledge about cognitive impairments preonset can provide a better basis for understanding the complex pathogenesis of SSD as well as informing cognitive remediation programs.
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