Evidence map›Paper›PMID 35251709›Full record

ArticleJournal of ophthalmology2022

miR-486-5p Restrains Extracellular Matrix Production and Oxidative Damage in Human Trabecular Meshwork Cells by Targeting TGF-

Le Xu, Yiming Zhang, Hua Long, Bo Zhou, Haibo Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Le Xu *Department of Ophthalmology, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, Hubei, China.ORCID https://orcid.org/0000-0001-5060-9066
Yiming Zhang *Department of Orthopedics, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, Hubei, China.ORCID https://orcid.org/0000-0002-0845-9890
Hua LongDepartment of Ophthalmology, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, Hubei, China.ORCID https://orcid.org/0000-0002-3964-7069
Bo ZhouDepartment of Ophthalmology, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, Hubei, China.ORCID https://orcid.org/0000-0002-6389-5230
Haibo JiangDepartment of Ophthalmology, Suizhou Hospital, Hubei University of Medicine, Suizhou 441300, Hubei, China.ORCID https://orcid.org/0000-0003-0939-2154
Hubei University of Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlaucoma is characterized by elevated intraocular pressure caused by aqueous outflow dysfunction. Trabecular meshwork plays a key role in controlling intraocular pressure by modulating aqueous outflow. This study investigated the protective effects of miR-486-5p in H

methodsTMCs were disposed with 300

resultsWe found that H

conclusionmiR-486-5p restrains H

Identifiers

PMID35251709
PMCPMC8890899
OpenAlexW4213432357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.