ArticleMicrosystems & nanoengineering2022
Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer.
Article in Microsystems & nanoengineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Atomic Layer Deposition Processes: Versatile Platforms for Engineering ZnO-Chitosan Biointerfaces.Advanced healthcare materials · 2026Article
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Soft Neural Interfaces for Circuit-Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models.Advanced healthcare materials · 2026Article
- Systematic evaluation of surgical insertion of flexible neural probe arrays into deeper brain targets using length modulation methods.Journal of neural engineering · 2026Article
- Rigid-Flexible Neural Optrode with Anti-Bending Waveguides and Locally Soft Microelectrodes for Multifunctional Biocompatible Neural Regulation.Micromachines · 2025Article
- Monolithic three-dimensional neural probes from deterministic rolling of soft electronics.Nature electronics · 2025Article
- Design, Fabrication, and Implantation of Invasive Microelectrode Arrays as in vivo Brain Machine Interfaces: A Comprehensive Review.Journal of manufacturing processes · 2024Article
- Enhancing Flexible Neural Probe Performance via Platinum Deposition: Impedance Stability under Various Conditions and In Vivo Neural Signal Monitoring.Micromachines · 2024Article
- Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cracking modes and force dynamics in the insertion of neural probes into hydrogel brain phantom.Journal of neural engineering · 2024Article
- Flexible neural probes: a review of the current advantages, drawbacks, and future demands.Journal of Zhejiang University. Science. B · 2024Review
- Flexible high-density microelectrode arrays for closed-loop brain-machine interfaces: a review.Frontiers in neuroscience · 2024Review
- Implantable intracortical microelectrodes: reviewing the present with a focus on the future.Microsystems & nanoengineering · 2023Review
- Low-temperature processing of screen-printed piezoelectric KNbOMicrosystems & nanoengineering · 2023Article
- Advancing the interfacing performances of chronically implantable neural probes in the era of CMOS neuroelectronics.Frontiers in neuroscience · 2023Review
- Nanomaterial-based microelectrode arrays for in vitro bidirectional brain-computer interfaces: a review.Microsystems & nanoengineering · 2023Review
- Article
- Manufacturing Processes of Implantable Microelectrode Array for In Vivo Neural Electrophysiological Recordings and Stimulation: A State-Of-the-Art Review.Journal of micro- and nano-manufacturing · 2022Article
- Electrical and Optical Characterization of SAW Sensors Coated with Parylene C and Their Analysis Using the Coupling-of-Modes (COM) Theory.Sensors (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flexible intracerebral probes for neural recording and electrical stimulation have been the focus of many research works to achieve better compliance with the surrounding tissue while minimizing rejection. Strategies have been explored to find the best way to insert flexible probes into the brain while maintaining their flexibility once positioned. Here, we present a novel and versatile scalable batch fabrication approach to deliver ultrathin and flexible probes consisting of a silk-parylene bilayer. The biodegradable silk layer, whose degradation time is programmable, provides a temporary and programmable stiffener to allow the insertion of ultrathin parylene-based flexible devices. Our innovative and robust batch fabrication technology allows complete freedom over probe design in terms of materials, size, shape, and thickness. We demonstrate successful ex vivo insertion of the probe with acute high-fidelity recordings of epileptic seizures in field potentials as well as single-unit action potentials in mouse brain slices. Our novel technological solution for implanting ultraflexible devices in the brain while minimizing rejection risks shows high potential for use in both brain research and clinical therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.